The prognostic significance of Src and p-Src expression in patients with osteosarcoma

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Chao HuYuanlong Xie

Abstract

The expression of Src and phospho-Src (p-Src) is closely related to tumor invasion and metastasis. The aim of the present study was to investigate the expression of these molecules in osteosarcoma and their relationship with each other, to provide a theoretical basis to understand the prognosis of osteosarcoma. We selected surgically resected osteosarcoma specimens from 116 patients of Zhongnan Hospital of Wuhan University and Hubei Cancer Hospital, Hubei, China, between January 2000 and January 2010 with detailed follow-up data. Twenty osteochondroma specimens from the corresponding period were used as controls. Expression of Src and p-Src was detected in osteosarcoma and osteochondroma by immunohistochemistry. We analyzed the relationship of the 2 proteins and osteosarcoma patient prognosis. The expression of Src and p-Src in osteosarcoma was significantly higher than the expression level in osteochondroma (P<0.05). The expression levels of the 2 proteins, clinical stage, and tumor metastasis were significantly associated with survival time (P<0.05), but there was no correlation between age or sex and survival time. The expression of Src and p-Src in osteosarcoma was positively correlated. Src and p-Src can be used as an auxi...Continue Reading

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Citations

Apr 9, 2016·International Journal of Molecular Sciences·Atik Badshah ShaikhGe Zhang
Feb 14, 2018·British Journal of Cancer·Victoria K WoodcockMark R Middleton
Jul 4, 2017·Journal of Cellular Physiology·Enrica UrciuoliBarbara Peruzzi
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Jul 1, 2020·Current Treatment Options in Oncology·Florence Duffaud
May 26, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Bo-Chuan LinFeng-Jun Shi
Feb 7, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yu-Xin ZhaoCai-Li Guo
Jan 29, 2021·Molecular and Cellular Biochemistry·Mona G El-SisiHala O El-Mesallamy
Aug 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chao HuLin Cai

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