The prognostic significance of tall cells in papillary thyroid carcinoma: A case-control study

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Sebastian StenmanJohanna Arola

Abstract

The subtype of the papillary thyroid carcinoma tall-cell variant has a worse prognosis than does the conventional papillary type (papillary thyroid carcinoma). The new World Health Organization 2017 classification defines a tall-cell variant as a tumour consisting of over 30% of cells that are two or three times as tall as they are wide. However, thresholds have differed. Our aim was to study how tall cells affect the prognosis of papillary thyroid carcinoma patients and to determine, for such cells, a cut-off percentage. Our cohort included 65 papillary thyroid carcinoma patients who underwent surgery at Helsinki University Hospital between 1973 and 1996: originally, 36 otherwise-matched patient pairs, eventually comprising 34 patients with an adverse outcome plus 31 who had recovered. All samples were digitally scanned and scored by two investigators based on tall cell composition. The cohort was analysed with four tall cell thresholds: 10%, 30%, 50% and 70% with a median follow-up of 22 years. In survival analysis, only the 70% threshold showed a correlation with reduced overall survival, disease-specific survival and relapse-free survival. A correlation also emerged with death from papillary thyroid carcinoma. In multivaria...Continue Reading

References

Jan 1, 1976·Cleveland Clinic Quarterly·W A Hawk, J B Hazard
Jan 1, 1988·The American Journal of Surgical Pathology·T L JohnsonJ C Sisson
Nov 1, 1994·American Journal of Surgery·J H TerryJ R Marti
Jan 1, 1997·World Journal of Surgery·A RüterS Lennquist
Jan 13, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·E L Mazzaferri
May 5, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Päivi SiironenCaj Haglund
Nov 14, 2006·Human Pathology·Jean Jacques MichelsStephane Bardet
Aug 19, 2007·Thyroid : Official Journal of the American Thyroid Association·Ronald A GhosseinR Michael Tuttle
Nov 21, 2007·The Laryngoscope·Alex Kwok-Cheung LeungStephen C K Law
Oct 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Ronald Ghossein, Virginia A Livolsi
Apr 6, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Virginia A LiVolsi
Nov 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Ian GanlyRonald Ghossein
Feb 22, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, H Gilbert Welch
Oct 17, 2014·Thyroid : Official Journal of the American Thyroid Association·Tomas A AxelssonJon G Jonasson
Apr 15, 2015·Endocrine-related Cancer·Matthias S DettmerAurel Perren
Nov 4, 2015·The Journal of Clinical Endocrinology and Metabolism·Xiaoguang ShiMingzhao Xing
Dec 15, 2017·Histopathology·Zubair W Baloch, Virginia A LiVolsi

❮ Previous
Next ❯

Citations

Jul 24, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Sara Cartwright, Abbey Fingeret

❮ Previous
Next ❯

Software Mentioned

MedCalc
SPSS
SAS
WebMicroscope

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.