The prognostic significance of the 2014 International Society of Urological Pathology (ISUP) grading system for prostate cancer

Pathology
Hemamali SamaratungaJohn Yaxley

Abstract

The 2005 International Society of Urological Pathology (ISUP) modified Gleason grading system was further amended in 2014 with the establishment of grade groupings (ISUP grading). This study examined the predictive value of ISUP grading, comparing results with recognised prognostic parameters.Of 3700 men undergoing radical prostatectomy (RP) reported at Aquesta Pathology between 2008 and 2013, 2079 also had a positive needle biopsy available for review. We examined the association between needle biopsy 2014 ISUP grade and 2005 modified Gleason score, tumour volume, pathological stage of the subsequent RP tumour, as well as biochemical recurrence-free survival (BRFS). The median age was 62 (range 32-79 years). Median serum prostate specific antigen was 5.9 (range 0.4-69 ng/mL). For needle biopsies, 280 (13.5%), 1031 (49.6%), 366 (17.6%), 77 (3.7%) and 325 (15.6%) were 2014 ISUP grades 1-5, respectively. Needle biopsy 2014 ISUP grade showed a significant association with RP tumour volume (p < 0.001), TNM pT and N stage (p < 0.001) and BRFS (p < 0.001). Multivariate analysis using Cox proportional hazards regression model showed serum prostate specific antigen (PSA) at the time of diagnosis and ISUP grade >2 to be significantly as...Continue Reading

References

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Citations

Aug 13, 2015·Histopathology·Brett DelahuntJohn R Srigley
Mar 24, 2016·Expert Review of Anticancer Therapy·Rodolfo MontironiMarina Scarpelli
May 7, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lars EgevadHemamali Samaratunga
Mar 30, 2016·The American Journal of Surgical Pathology·Lars EgevadJohn R Srigley
Jul 15, 2016·Scandinavian Journal of Urology·Hemamali SamaratungaLars Egevad
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Jan 30, 2019·Pathology International·Lars EgevadHemamali Samaratunga
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Feb 27, 2020·Archives of Pathology & Laboratory Medicine·Travis Rice-StittChin-Lee Wu
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May 18, 2019·Virchows Archiv : an International Journal of Pathology·Marit LucasHenk A Marquering

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

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