The prognostic validity of the ventricular evoked response (VER) signals in cardiac transplantation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Martin SchweigerKarlheinz Tscheliessnigg

Abstract

Computerized heart allograft rejection monitoring (CHARM) used for non-invasive rejection monitoring in heart transplant recipients is based on the analysis of ventricular evoked response (VER) signals. The aim of this study was to evaluate the prognostic validity of the Tslew(C), a parameter calculated from the VER. During orthotopic heart transplantation, 2 unipolar fractally coated screw-in leads were implanted epimyocardially, one to the left and one to the right ventricle, and connected to a telemetric pacemaker. Recordings of intramyocardial electrograms were performed routinely at the hospital. Data processing was done, artifacts were eliminated, and trend curves of the patients were displayed. Tslew(C) was calculated from the tangent of VER and evaluated from 105 patients. The patients were divided into survivor and non-survivor groups. For statistical analysis, the 2-tailed t-test was performed. Patients in the non-survivors group compared with the control group showed a significantly lower Tslew(C) in the final follow-up (p < 0.001). The differences were even more impressive in patients with recorded intramyocardial electrograms 30 days before death or with a cardiac reason for death. Tests were performed to find an o...Continue Reading

References

Oct 17, 1998·The Thoracic and Cardiovascular Surgeon·B M RichartzO H Frazier
Nov 24, 1998·Pacing and Clinical Electrophysiology : PACE·B GrasserK Tscheliessnigg
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·B GrasserK H Tscheliessnigg
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B GrasserK Tscheliessnigg
Apr 11, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R E HershbergerR A Wilson
Jun 19, 2001·Transplantation Proceedings·D KniepeissK H Tscheliessnigg
May 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Guglielma Rita CilibertoMaria Frigerio
Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael DandelRoland Hetzer
Aug 3, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorMarshall I Hertz

❮ Previous
Next ❯

Citations

Sep 17, 2014·Biomarkers in Medicine·Jenna F McMinnRoy S Gardner
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M GrimmG Laufer
Expert Opinion on Drug Metabolism & Toxicology
Maria ShipkovaEberhard Wieland
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
William T MahleKirk R Kanter
© 2021 Meta ULC. All rights reserved