The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer

Cancer
Mostafa M El-SerafiAbdel-Rahman N Zekri

Abstract

The prognosis for patients with colorectal cancer (CRC) depends mainly on standard clinicopathologic factors. However, patients with similar disease characteristics exhibit various outcomes, especially in stage II. Therefore, the identification of molecular prognostic markers is needed to predict patient outcomes. The authors assessed the prognostic value of c-Kit (also called cluster of differentiation 117 [CD117] or KIT), cyclooxygenase-2 (COX-2), tumor protein 53 (p53), and Kirsten rat sarcoma viral oncogene homolog (K-ras) aberrations in 90 patients with stage II CRC using immunohistochemistry and molecular techniques. The results were correlated with standard clinicopathologic prognostic factors, overall survival (OS), and disease-free survival (DFS). COX2 and c-Kit overexpression was detected in 54.6% and 59.3% of patients, respectively. Overexpression of p53 was detected in 47 patients, including 29 who had mutations, and a unique mutation pattern was detected with 3 hotspots at codons 72, 245, and 273. Overexpression of ras was detected in 44 patients, including 37 who had mutations. On multivariate analysis, c-Kit overexpression, p53 codon 72 mutations, perforation, and performance status were independent prognostic fa...Continue Reading

References

Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Dec 15, 1994·International Journal of Cancer. Journal International Du Cancer·B R DixB J Iacopetta
Jul 8, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H BouzoureneJ C Givel
Oct 25, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R SoongB Iacopetta
Apr 6, 2001·Diseases of the Colon and Rectum·S PetersenM Baumann
Apr 20, 2001·Journal of the National Cancer Institute·H NelsonUNKNOWN National Cancer Institute Expert Panel
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A ForslundK Lundholm
Sep 5, 2001·British Journal of Cancer·H J AndreyevN Urosevic
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Wade S SamowitzMartha L Slattery
May 11, 2002·The American Journal of Gastroenterology·Hong Zhang, Xiao-Feng Sun
Nov 28, 2002·Clinical Colorectal Cancer·Jennifer ReedDomenico Coppola
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carmen J AllegraH Samuel Wieand
Apr 1, 2003·Advances in Experimental Medicine and Biology·Alane KokiJaime L Masferrer
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Graziano, S Cascinu
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca YorkeMamoun Younes
Dec 13, 2003·Urologic Oncology·Hussein M KhaledNadia Mokhtar
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph P DieterleMartin R Berger
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Murray B ResnickVictor E Pricolo
May 11, 2004·International Journal of Colorectal Disease·Innocenzo SammarcoRaffaele Geremia
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Al B BensonDaniel G Haller
Sep 24, 2004·BMC Gastroenterology·Abeer A BahnassyMostafa El-Serafi
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard FuxPeter Fritz
Sep 17, 2005·Pathology, Research and Practice·Deniz YamacFulya Koybasioglu
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annie O ChanStanley R Hamilton
Dec 17, 2005·Journal of Zhejiang University. Science. B·Dan-ping ZhaoSu-zhan Zhang
May 25, 2006·Medical Oncology·Wesam A NasifNabil Gad El-Hak
May 10, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y WangA Helland
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yutaka SuehiroStanley R Hamilton

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Citations

Dec 19, 2012·Journal of Agricultural and Food Chemistry·Ying Yng ChoyAndrew L Waterhouse
Jul 20, 2012·Diseases of the Colon and Rectum·JiaoJiao RenYaShuang Zhao
Oct 15, 2014·Cell Communication and Signaling : CCS·Hui XiaoJan Lötvall
Mar 22, 2018·Archives of Physiology and Biochemistry·Afaf ElsaidCamelia Abdel-Malak
Jul 3, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew T KunzmannMarie M Cantwell
Mar 5, 2021·Frontiers in Oncology·Solomon O RotimiBodour Salhia

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