The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after >10 years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA)

International Journal of Cardiology
Miguel Cainzos-AchiricaMichael J Blaha

Abstract

The prognostic value of hsCRP in contemporary multi-ethnic populations is unclear, particularly in statin users. The aim of this study was to characterize the prognostic utility of hsCRP for atherosclerotic CVD (ASCVD) risk prediction in a multi-ethnic population including non-users and users of statins followed for >13 years. Associations with heart failure (HF), atrial fibrillation (AF), venous thromboembolism (VTE), cancer, and all-cause death were also examined. We evaluated 6757 participants from the Multi-Ethnic Study of Atherosclerosis (MESA; 1002 using statins at baseline), median follow-up 13.2 years. Higher levels of hsCRP were associated with a higher risk of all study endpoints in the unadjusted Cox Proportional Hazards regression analyses, except AF. Among non-users of statins, hsCRP only remained associated with VTE after adjusting for ASCVD risk factors, and did not improve risk prediction. Among users of statins, hsCRP did not improve ASCVD risk prediction either, although it was strongly associated with incident HF (HR for hsCRP ≥ 2 vs <2 mg/L 3.99; 95% CI 2.02, 7.90) and all-cause death (HR 1.52; 95% CI 1.11, 2.08) in multivariable analyses, and hsCRP significantly improved prediction of HF (area under the cur...Continue Reading

Citations

Jul 11, 2018·Current Cardiology Reports·Miguel Cainzos-AchiricaMichael J Blaha
Sep 27, 2019·Advances in Nutrition·Kristin M HirahatakeSean H Adams
Dec 14, 2018·International Journal of Molecular Sciences·Rosa CasasEmilio Sacanella
Nov 2, 2020·JACC. Cardiovascular Imaging·Alexander C RazaviSeamus P Whelton
Mar 13, 2021·Biomarkers in Medicine·Douglas Gj McKechnieS Goya Wannamethee

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