The Prognostic Value of Laboratory Markers and Ambulatory Function at Presentation for Post-Treatment Morbidity and Mortality Following Epidural Abscess

Spine
Brian C GohAndrew J Schoenfeld

Abstract

Retrospective cohort study. To develop a comprehensive understanding of the prognostic value of laboratory markers on morbidity and mortality following epidural abscess. Spinal epidural abscess is a serious medical condition with high rates of morbidity. The value of laboratory data in forecasting morbidity and mortality after epidural abscess remains underexplored. We obtained clinical data on patients treated for epidural abscess at two academic centers from 2005 to 2017. Our primary outcome was the development of one or more complications within 90-days of presentation, with mortality a secondary measure. Primary predictors included serum albumin, serum creatinine, platelet-lymphocyte ratio, and ambulatory status at presentation. We used multivariable logistic regression techniques to adjust for confounders. The most parsimonious set of variables influencing both complications and mortality were considered to be clinically significant. These were then examined individually and in combination to assess for synergy along with model-discrimination and calibration. We performed internal validation with a bootstrap procedure using sampling with replacement. We included 449 patients in this analysis. Complications were encountered...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Nov 10, 2006·The New England Journal of Medicine·Rabih O Darouiche
Jan 1, 2014·The Spine Journal : Official Journal of the North American Spine Society·Sang Do KimMitchel B Harris
Sep 23, 2014·The Spine Journal : Official Journal of the North American Spine Society·Andrew J Schoenfeld, Trevor C Wahlquist
Sep 28, 2015·The Spine Journal : Official Journal of the North American Spine Society·Andrew J SchoenfeldMitchel B Harris
Oct 17, 2017·The Spine Journal : Official Journal of the North American Spine Society·Diana D ShiLauren M Hertan
Jun 20, 2018·The Journal of Bone and Joint Surgery. American Volume·Akash A ShahJoseph H Schwab
Dec 1, 2018·World Neurosurgery·Aditya V KarhadeJoseph H Schwab
Feb 15, 2019·The Spine Journal : Official Journal of the North American Spine Society·Aditya V KarhadeJoseph H Schwab
May 28, 2019·The Spine Journal : Official Journal of the North American Spine Society·Andrew J SchoenfeldJoseph H Schwab

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