Abstract
We aim to evaluate the prognostic value of metastatic lymph node number (MLN) and ratio (MLR) in oesophageal squamous cell carcinoma (OSCC) patients with or without neoadjuvant chemoradiation. Two thousand one hundred and fifty-one OSCC patients receiving oesophagectomy with (n = 850) or without (n = 1301) neoadjuvant chemoradiation were included. The MLN was categorized into 0 (N0), 1-2 (N1), 3-6 (N2) and more than 7 (N3); the MLR was categorized into 0, 0-0.2 and >0.2. The prognostic value was evaluated with survival analysis using the Cox proportional hazards regression model and the Kaplan-Meier method. In patients without neoadjuvant chemoradiation, the 3-year overall survival rates were 54.8, 34.4, 21.8 and 6.5% with MLN = 0, 1-2, 3-6 and more than 7, respectively (P < 0.001). The 3-year overall survival rates were 54.7, 31.2 and 14.2% with MLR = 0, 0-0.2 and more than 0.2, respectively (P < 0.001). In patients with neoadjuvant chemoradiation, the 3-year overall survival rates were 49.0, 28.4, 12.5 and 0.0% with MLN = 0, 1-2, 3-6 and more than 7, respectively (P < 0.001). However, the survival curves of MLN = 3-6 and MLN ≥7 overlapped on the Kaplan-Meier plots. In contrast, MLR demonstrated good ability to show the surviv...Continue Reading
References
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nabil P RizkUNKNOWN American Joint Committee on Cancer
Jan 25, 2008·Annals of Surgery·Christophe MarietteJean Pierre Triboulet
Jul 30, 2008·Annals of Surgical Oncology·Andrew P BarbourB Mark Smithers
Feb 7, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T W RiceE H Blackstone
Aug 13, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wen-Hu HsuYu-Chung Wu
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 27, 2010·The Annals of Thoracic Surgery·Po-Kuei HsuWen-Hu Hsu
Dec 14, 2011·Journal of Surgical Oncology·Yasunori AkutsuHisahiro Matsubara
Mar 8, 2012·Annals of Surgical Oncology·Koen TalsmaBas P L Wijnhoven
Apr 12, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Brendon M StilesNasser K Altorki
May 18, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S P MehtaH I Grabsch
May 25, 2012·The Annals of Thoracic Surgery·Castigliano M BhamidipatiDavid R Jones
Mar 1, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shao-Bin ChenHao Zhang
Mar 13, 2014·The Annals of Thoracic Surgery·Po-Kuei HsuWen-Hu Hsu
Aug 27, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Zihui TanPeng Lin
Nov 2, 2014·Annals of Surgery·William B RobbUNKNOWN Fédération Française de Cancérologie Digestive, Société Française de Radiothérapie Oncologique, Union des Centres de Lutte C
Nov 8, 2014·Annals of Surgery·A Koen TalsmaHugo W Tilanus
Jan 21, 2015·Japanese Journal of Clinical Oncology·Chun-Ju ChiangMei-Shu Lai
Jul 3, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Zhong-hua NingJing-ting Jiang
Jul 4, 2015·World Journal of Gastroenterology : WJG·Shao-Bin ChenHao Zhang
Citations
Aug 15, 2018·The British Journal of Surgery·S MineN Ishizuka
Feb 23, 2020·Annals of Surgical Oncology·Chih-Ming LinHan-Shui Hsu
Jan 13, 2018·Scientific Reports·Joonas H KauppilaJesper Lagergren
Nov 21, 2020·Annals of Surgical Oncology·Po-Kuei HsuHan-Shui Hsu
Nov 17, 2020·Frontiers in Oncology·Yan ZhengWenqun Xing
Aug 28, 2021·Cancers·Chellan KumarasamyRama Jayaraj