The prognostic value of multiorgan metastases in patients with non-small cell lung cancer and its variants: a SEER-based study

Journal of Cancer Research and Clinical Oncology
Jie YangYueye Huang

Abstract

This study aimed to investigate the prognostic value of different organs metastases in patients with non-small cell lung cancer (NSCLC) and its most common subtypes. We identified 45,423 NSCLC cases (25,129 men and 20,294 women) between 2010 and 2013 with distant metastases, with complete clinical information obtained from the surveillance, epidemiology, and end results (SEER) database. Bone and liver were the most and the least common metastatic sites with rates of 37.1 and 16.8%, respectively. The mortality rates associated with bone, brain, liver, lung metastases, and multiorgan metastases (MOM) were 73.2, 72.7, 78.3, 65.4, and 77.5%, respectively. Kaplan-Meier analyses demonstrated that patients with MOM and liver metastasis had the worst survival. Compared with NSCLC cases with other organ metastasis, but without the four organs metastasis, hazard ratios (HRs) for lung, bone, brain, and liver metastases, and MOM were 0.906 (95% CI 0.866-0.947), 1.276 (95% CI 1.225-1.330), 1.318 (95% CI 1.260-1.379), 1.481 (95% CI 1.388-1.580), and 1.647 (95% CI 1.587-1.709), respectively. Similar results were obtained for adenocarcinoma (AD) cases. The mortality risk is highest with MOM and liver metastasis followed by bone, brain, other o...Continue Reading

References

Feb 24, 2001·Surgery Today·Y IchinoseUNKNOWN Japan Clinical Oncology Group
Jan 16, 2003·Chest·James R JettUNKNOWN American College of Chest Physicians
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Jan 16, 2008·Clinical Orthopaedics and Related Research·Hideshi SugiuraTetsuya Mitsudomi
Sep 16, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel MorgenszternRamaswamy Govindan
Dec 3, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel MorgenszternRamaswamy Govindan
Feb 24, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T BrodowiczC Manegold
Dec 4, 2012·Oncology Letters·Kensuke NakazawaNobuyuki Hizawa
Mar 19, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Julio Sánchez de Cos EscuínHelena Hernández Rodríguez
May 3, 2014·Therapeutic Advances in Medical Oncology·Chiara D'AntonioFilippo de Marinis
Aug 19, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M RiihimäkiK Hemminki
Dec 4, 2014·Molecular and Clinical Oncology·Tomohiro TamuraNobuyuki Hizawa
Jul 3, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tomohiko IidaUNKNOWN Japanese Joint Committee of Lung Cancer Registry
Sep 12, 2015·American Journal of Clinical Oncology·Saiama N WaqarDaniel Morgensztern
Nov 5, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Wilfried E E EberhardtUNKNOWN International Association for Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Board Members, and Par
Oct 27, 2016·Chest·Frank C DetterbeckLynn T Tanoue
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 1, 2017·CA: a Cancer Journal for Clinicians·Ramón Rami-PortaValerie W Rusch
Sep 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T BrodowiczC Manegold

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Citations

Jul 17, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Shao-Bo BaiSi-Yuan Zhou
Jun 25, 2021·Cancer Management and Research·Oliver Higuera GómezLaia Vilà

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