The prognostic value of neutrophil-to-lymphocyte ratio on mortality in critically ill trauma patients

The Journal of Trauma and Acute Care Surgery
Evren DilektasliDemetrios Demetriades

Abstract

Recent studies suggest that the neutrophil-lymphocyte ratio (NLR) as a marker of inflammation is associated with mortality in surgical patients. The aim of this study was to determine the prognostic impact of NLR in critically ill trauma patients. This is a retrospective cohort study involving all trauma patients 16 years or older admitted to the surgical intensive care unit of a Level 1 trauma center (January 2013 to January 2014). The predictive capacity of NLR on mortality was assessed using a receiver operating characteristic curve analysis. To identify the effect of the NLR on survival, a separate log-rank test was used. Multivariable Cox proportional hazard modeling was used to identify independent predictors of mortality. During the study period, 1,356 patients met inclusion criteria. Of these, 74% were male, 86% sustained blunt trauma, and the median age was 49 years (interquartile range [IQR], 35). The median Glasgow Coma Scale (GCS) score and Injury Severity Score (ISS) were 15 (IQR, 3) and 13 (IQR, 14), respectively. With the use of the receiver operating characteristic curve analyses at intensive care unit Days 2 and 5, optimal NLR cutoff values of 8.19 and 7.92 were calculated by maximizing the Youden index. Kaplan...Continue Reading

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References

Jan 1, 1988·The Journal of Trauma·W S CopesL W Bain
Jul 1, 1980·American Journal of Surgery·C C BakerD D Trunkey
Feb 1, 1995·The Journal of Trauma·A SauaiaP T Pons
Jan 1, 1994·Archives of Surgery·A SauaiaD C Lezotte
Sep 29, 1998·The Journal of Trauma·S R HeckbertR V Maier
Aug 10, 2002·The Journal of Trauma·Grant V BochicchioThomas M Scalea
Jun 3, 2004·Langenbeck's Archives of Surgery·Michael D Menger, Brigitte Vollmar
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Nov 29, 2005·Journal of the American College of Surgeons·James L GuzzoThomas M Scalea
May 9, 2006·Microbes and Infection·Charles M Robertson, Craig M Coopersmith
Mar 28, 2007·International Journal of Surgery·Emily J CookNeil J Keeling
Aug 19, 2007·The Journal of Trauma·Robert A CherryRobert N Cooney
Oct 31, 2007·American Heart Journal·Patrick H GibsonGraham S Hillis
May 24, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Angela PapaFranca Cocci
Feb 3, 2009·The Journal of Thoracic and Cardiovascular Surgery·Khaled M SarrafEric Lim
Sep 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaMatsuo Nagata
Nov 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Cornelis P C de JagerPeter C Wever
Jan 24, 2012·Critical Care : the Official Journal of the Critical Care Forum·Daithi S HeffernanAlfred Ayala
Mar 1, 2012·International Journal of Surgery·P G Vaughan-ShawA T King
Aug 28, 2012·Dementia and Geriatric Cognitive Disorders·Mehmet Emin KuyumcuServet Arıoğul
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Mehmet CelikbilekMehmet Yücesoy
Apr 23, 2013·Critical Reviews in Oncology/hematology·Graeme J K GuthrieStephen J Clarke
Jan 9, 2014·Innate Immunity·Markus AlbertsmeierMartin K Angele
Sep 6, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ünal UlucaMuhammed Sabas
Sep 25, 2014·The Journal of Trauma and Acute Care Surgery·David C DewarZsolt J Balogh
Jan 15, 2015·American Journal of Surgery·Joanna SzkanderaMartin Pichler

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Citations

Dec 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Florence RichéDidier Payen
Oct 11, 2012·PloS One·Cornelis P C de JagerRobert J F Laheij
Dec 20, 2011·The Journal of Urology·Yoshio OhnoMasaaki Tachibana
Nov 3, 2016·The Journal of Trauma and Acute Care Surgery·Joon Min Park
Aug 25, 2017·The Journal of Trauma and Acute Care Surgery·Juan Carlos DuchesneMansoor Khan
Sep 12, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Luis Alfonso Ortiz-ReyesDaniel Dante Yeh
Oct 27, 2017·Infectious Diseases·Stamatis KarakonstantisCharalampos Lydakis
Feb 8, 2019·International Orthopaedics·Luchian AlexandruDaliborca Cristina Vlad
Feb 23, 2017·NeuroRehabilitation·Ashley B PetroneTaura L Barr
Oct 20, 2020·The Journal of Trauma and Acute Care Surgery·Pieter de JagerGuy A Richards
Apr 24, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Adilson J M de OliveiraWellingson S Paiva
Apr 22, 2021·Burns : Journal of the International Society for Burn Injuries·Emre KarakayaMehmet Haberal

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