The Prognostic Value of Patient-Reported Outcome Data in Patients With Colorectal Hepatic Metastases Who Underwent Surgery

Clinical Colorectal Cancer
J R ReesJ M Blazeby

Abstract

Patient-reported outcomes (PROs) are critical to evaluate clinically effective treatments and evidence suggests that PROs might predict survival. The prognostic value of PROs in patients with isolated liver metastases from colorectal cancer (CRC) who undergo surgery is unclear. In this study we investigated whether baseline PROs are prognostic in this patient group. From April 2004 to May 2007, consecutive patients who underwent curative resection of CRC liver metastases completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ)-C30 and QLQ-LMC21 questionnaires before surgery. Patients were followed until death or data were censored on April 9, 2012. Cox proportional hazards models were used to assess the effect of PROs on survival controlling for predefined clinical covariates. Models were simplified using a backwards stepwise approach and model utility appraised using the Harrell C and Somers D statistics and bootstrap methods. Two hundred thirty-two patients underwent liver resection and 101 (43.5%) survived 5 years. Multivariate analysis controlling for relevant clinical covariates showed that a 10-point improvement in baseline global quality of life scores was associated wi...Continue Reading

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Citations

Feb 2, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Fabio EfficaceMarco Vignetti
Apr 17, 2021·Nature Reviews. Disease Primers·Diamantis I TsilimigrasTimothy M Pawlik
Nov 7, 2021·World Neurosurgery·Eagan J PetersDemitre Serletis

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