The prognostic value of perioperative, pre-systemic therapy CA125 levels in patients with high-grade serous ovarian cancer

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Taymaa MayBarry Rosen

Abstract

To investigate the ability of preoperative CA125 and post-surgical CA125 changes to predict outcomes among patients with high-grade serous ovarian cancer (HGSC). The present retrospective cohort study included patients with HGSC who underwent surgery between January 1, 2003, and December 31, 2011 at Princess Margaret Cancer Center, Toronto, ON, Canada. CA125 was measured at diagnosis and following surgery, and the CA125 ratio was calculated (preoperative CA125/postoperative CA125). Optimal CA125 cutoff levels were identified using the point with the most significant log-rank-test result. Univariate and multivariate analyses with Cox proportional hazard modeling was used to study overall survival. Among 212 patients, an optimal baseline CA125 cutoff value of 174 U/mL and a seven-fold decrease in CA125 after surgery were positive prognostic indicators. A 10-fold increase in baseline CA125 was associated with decreased overall survival (univariate hazard ratio 1.55, 95% confidence interval [CI] 1.17-2.06; P=0.002; multivariate hazard ratio 1.72, 95% CI 1.21-2.44; P=0.002). An increase in the CA125 ratio (log10 [preoperative CA125/postoperative CA125]) was associated with improved overall survival (univariate hazard ratio 0.63, 95%...Continue Reading

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Citations

May 23, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ingrid LaiTomer Feigenberg
Jul 1, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Taymaa May, Amit M Oza
Jan 28, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Qiujie MaWei Feng
Jun 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shengqing GuBenjamin G Neel

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