The prognostic value of phosphorylated AKT expression in non-small cell lung cancer: a meta-analysis

PloS One
Zhi-Xin QiuWei-Min Li

Abstract

Phosphorylated AKT (p-AKT), constitutive activation of AKT, is a potentially interesting prognostic marker and therapeutic target in non-small cell lung cancer (NSCLC). However, the available results of p-AKT expression in NSCLC are heterogeneous. Therefore, a meta-analysis of published researches investigating the prognostic relevance of p-AKT expression in patients with NSCLC was performed. A literature search via PubMed, EMBASE and CNKI (China National Knowledge Infrastructure) databases was conducted. Data from eligible studies were extracted and included into meta-analysis using a random effects model. A total of 1049 patients from nine studies were included in the meta-analysis. Nine studies investigated the relationship between p-AKT expression and overall survival using univariate analysis, and five of these undertook multivariate analysis. The pooled hazard ratio (HR) for overall survival was 1.49 (95% confidence interval (CI): 1.01-2.20) by univariate analysis and 1.02 (95% CI: 0.54-1.95) by multivariate analysis. Our study shows that positive expression of p-AKT is associated with poor prognosis in patients with NSCLC. However, adequately designed prospective studies need to perform.

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Citations

Jun 24, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Cheng-Yi WangKuen-Feng Chen
May 11, 2019·Nutrition and Cancer·Wipa ChantarawongPithi Chanvorachote
Jun 30, 2019·Biomolecules·Nand Kishor RoyAjaikumar B Kunnumakkara
Dec 15, 2015·Oncotarget·S Elizabeth FranksRoger A Moorehead
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zhi-Xin QiuWei-Min Li
Feb 13, 2021·International Journal of Molecular Sciences·Nadezhda V Popova, Manfred Jücker
Jul 17, 2021·Laboratory Medicine·Yongqiang LiDongwei Huang

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Methods Mentioned

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surgical resection

Software Mentioned

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GraphPad

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