The Prognostic Value of Plasma YKL-40 in Patients With Chemotherapy-Resistant Ovarian Cancer Treated With Bevacizumab

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Mogens K BoisenKarina D Steffensen

Abstract

YKL-40 is a proangiogenic glycoprotein that is secreted by cancer cells and inflammatory cells. The expression of YKL-40 is induced by vascular endothelial growth factor inhibition. We tested the hypothesis that low baseline plasma YKL-40 is associated with improved outcomes in patients with ovarian cancer treated with bevacizumab. One hundred forty patients with chemotherapy-refractory epithelian ovarian cancer were treated with single-agent bevacizumab 10 mg/kg every 3 weeks in a prospective trial. Plasma YKL-40 was determined by enzyme-linked immunosorbent assay before and during treatment. Both raw YKL-40 concentrations and age-corrected percentiles of normal YKL-40 level were used. Associations between plasma YKL-40 level and progression-free survival (PFS) and overall survival were tested using univariate and multivariate Cox proportional hazards models. Baseline plasma YKL-40 levels were higher in patients with poor performance status, less differentiated tumors, residual disease after primary surgery, higher than the median serum CA-125 level, and higher than the median serum vascular endothelial growth factor level. Age-corrected percentile of normal plasma YKL-40 greater than the lowest quartile (Q1, 85th percentile) ...Continue Reading

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Citations

Sep 20, 2019·Journal of Clinical Laboratory Analysis·Kaitai LiuSenxiang Yan
Feb 11, 2020·Frontiers in Immunology·Julia KzhyshkowskaTengfei Liu
Oct 19, 2019·Cancer Cell International·Bingxian BianLisong Shen
Apr 13, 2018·Technology in Cancer Research & Treatment·Malgorzata FuksiewiczMaria M Kowalska
Nov 21, 2019·Future Oncology·Carolyn E Haunschild, Krishnansu S Tewari

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