The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers

Urologic Oncology
Yasheng HuangYun Yen

Abstract

To investigate the prognostic significance of ribonucleotide reductase small subunit M2 (RRM2) in low- and intermediate-risk prostate cancer (PCa). A retrospective outcome study was conducted on 164 eligible PCa samples from the City of Hope (n = 90) and the Taipei Medical University (n = 74). The RRM2 protein levels were detected by immunohistochemistry. Biochemical recurrence was assessed using Kaplan-Meier and Cox proportional hazard analyses. Cell invasion assays, Ras/Raf, and matrix metallopeptidase 9 activities were determined to evaluate the role of RRM2 on invasiveness of PCa. Expression of RRM2 was significantly increased in patients with higher Gleason score, who had advanced T stage, and who were margin/capsule positive (P<0.05). Analysis revealed that the expression of RRM2 positively associated with biochemical recurrence of PCa in the City of Hope set (hazard ratio = 5.26; 95% CI 1.50-24.71) and the Taipei Medical University set (hazard ratio = 2.55; 95% CI 1.30-9.22). In stratification analysis, RRM2 was significantly correlated with poor outcome in patients with lower-risk PCa, including those with Gleason score 4 to 7, margin(-), capsule(-), and stage T1-T2. In patients with Gleason score 4 to 7, the risk of re...Continue Reading

References

Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·H FanJ A Wright
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
May 12, 2006·Molecular Cancer Research : MCR·Martin IllemannBoye Schnack Nielsen
Jun 8, 2006·Annual Review of Biochemistry·Pär Nordlund, Peter Reichard
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J StephensonPeter T Scardino
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiyong LiuYun Yen
Jan 30, 2007·Cancer Letters·Stacy Loeb, William J Catalona
Jan 8, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Peter G WellsAndrea W Wong
May 7, 2009·The Journal of Biological Chemistry·Yong-Wei ZhangYves Pommier
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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