The prognostic value of the AgNOR parameter in human breast cancer depends on the pRb and p53 status

Journal of Clinical Pathology
Massimo DerenziniDavide Treré

Abstract

The amount of argyrophilic nucleolar organiser regions (AgNORs) represents a cell kinetics parameter used in tumour pathology for prognostic purposes. AgNOR expression is directly related to the rate of ribosome biogenesis, which has been recently shown to be controlled also by the tumour suppressor proteins pRb and p53. To ascertain the relative prognostic value of AgNORs and of pRb and p53 expression in breast carcinoma. This study was carried out on 335 human primary breast carcinomas with a median follow up time of 108 months. AgNORs were measured by morphometric analysis on sections that had been selectively silver stained; expression of p53 and phosphorylated and non-phosphorylated pRb forms was assessed by immunohistochemistry. Patients were divided into groups with low (249) and high (86) AgNOR values; with normal (267) and mutated p53 (68); and with normal (256) and hyperphosphorylated or deleted pRb (79). Univariate analysis of disease free survival showed that AgNORs and the status of pRb and p53 were significantly related to the patients' clinical outcome. However, among the four groups characterised by different pRb and p53 status, the AgNOR parameter was not capable of distinguishing subgroups of patients with dif...Continue Reading

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Citations

Jun 27, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D TreréM Derenzini
Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Davide TreréMassimo Derenzini
Jul 16, 2008·Journal of Veterinary Internal Medicine·K Bundgaard-AndersenD Trerè
Dec 3, 2011·Pathology Research International·Hussain Gadelkarim AhmedIbraheem M Ashankyty
Apr 18, 2014·Cellular and Molecular Life Sciences : CMLS·Mohamed KodihaUrsula Stochaj
Dec 18, 2009·Cancer Investigation·Luciana G QuintanaEdivaldo H C de Oliveira
Apr 3, 2009·Micron : the International Research and Review Journal for Microscopy·Halil Demirtas
Jun 28, 2008·The American Journal of Pathology·Lorenzo MontanaroMassimo Derenzini
May 17, 2008·Micron : the International Research and Review Journal for Microscopy·Seçil Ilhan Yilmaz, Halil Demirtas
Dec 28, 2007·Acta histochemica·Maria Luiza S MelloUlrich Schenck
Jul 28, 2005·The FEBS Journal·Hushan YangBenigno C Valdez
Jan 31, 2009·Histopathology·Massimo DerenziniDavide Treré
Feb 4, 2009·Journal of Cutaneous Pathology·Georgia A CastroValdemiro C Sgarbieri
Aug 1, 2011·Journal of Investigative and Clinical Dentistry·Abhay R ChandakRitesh Wadhwani
May 5, 2016·Histochemistry and Cell Biology·Dariusz Stępiński
Nov 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Davide TreréMassimo Derenzini
Oct 9, 2018·Microscopy Research and Technique·Bubacar EmbalóElena Riet Correa Rivero
Jul 30, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Virginia ValoriKeith A Maggert
May 3, 2013·The Analyst·H Georg SchulzeRobin F B Turner
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Massimo DerenziniDavide Treré
Apr 4, 2021·Genes·Cecelia M HaroldSusan J Baserga

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