The prognostic value of the serum eicosapentaenoic acid to arachidonic acid ratio in relation to clinical outcomes after endovascular therapy in patients with peripheral artery disease caused by femoropopliteal artery lesions

Atherosclerosis
Keiichi HishikariMitsuaki Isobe

Abstract

The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery lesions, to determine whether it predicts clinical outcomes after endovascular therapy (EVT). We obtained serum EPA/AA ratios from 132 consecutive patients with PAD caused by femoropopliteal artery lesions before EVT. Patients were divided into two groups using the median value of serum EPA/AA ratios of the entire cohort; LOW group with the levels ≤0.30 (n = 66) and HIGH group >0.30 (n = 66). The incidence of major adverse events (MAE), including major adverse limb events (MALE) and death from any cause, was determined. At a median follow-up interval of 24 months, MALE occurred in 40 patients (30.3%) and 11 patients (8.3%) died. Kaplan-Meier curve analysis demonstrated the survival probability from MAE was significantly worse in patients with EPA/AA ratio under the median (long-rank test χ(2) = 16.4; p < 0.001). Multivariate Cox regression analysis showed critical limb ischemia (hazard ratio [HR]: 3.44; 95% confidence interva...Continue Reading

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Citations

Jan 24, 2020·Journal of Atherosclerosis and Thrombosis·Yuri ShojimaNobutaka Hattori
Feb 15, 2020·Critical Reviews in Food Science and Nutrition·Sergio DavinelliGiovanni Scapagnini
Jul 10, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Bram KremersArina Ten Cate-Hoek
Jan 28, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Naruhiko ItoTetsuo Sasano

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