Abstract
This study aimed to determine the prognostic value of the tumor shadow disappearance rate (TDR) on integrated PET/computed tomography (PET/CT) evaluation of solitary pulmonary nodules (SPNs) with low glucose uptake. From January 2008 to September 2010, 99 patients who underwent fluorine-18 fluorodeoxyglucose PET (F-FDG-PET)/CT scanning for the evaluation of SPNs with a maximum standardized uptake value (SUVmax) below 2.75 (2.5+10%) were retrospectively reviewed. Among the 99 SPNs from these patients, 67 were malignant and 32 were benign, based on surgical pathology. Differences in baseline characteristics between the two groups were examined by means of the independent t-test, the Mann-Whitney U-test, and the χ-test. To test the efficacy of TDR for determining malignancy, the sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and positive and negative likelihood ratios (LR+ and LR-, respectively) with 95% confidence intervals were calculated using the pathological test as the gold standard. Patients with malignant nodules were older than those with benign nodules (64.5 vs. 55.1 years, respectively, P<0.001) and had higher TDRs (0.8 vs. 0.3, respectively, P<0.001). The optimal cutoff point ...Continue Reading
References
Mar 1, 1996·The European Respiratory Journal·T BuryM Radermecker
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V J LoweR E Coleman
Mar 17, 2001·JAMA : the Journal of the American Medical Association·M K GouldD K Owens
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·K TakamochiY Nishiwaki
Jan 16, 2003·Chest·Bethany B TanUNKNOWN American College of Chest Physicians
Dec 12, 2003·The Annals of Thoracic Surgery·Morihito OkadaNoriaki Tsubota
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Morihito OkadaNoriaki Tsubota
Jun 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroaki NomoriKimiichi Uno
Aug 4, 2005·Journal of Thoracic Imaging·Shinichiro KajiwaraHiroshi Honda
May 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Morihito OkadaChiho Ohbayashi
Jan 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James W FletcherUNKNOWN VA SNAP Cooperative Studies Group
Sep 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hubert VesselleDouglas E Wood
Feb 6, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Olga KagnaLuda Guralnik
Jun 23, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chih-Yung ChangChing-Yee Oliver Wong
Nov 21, 2009·Physics in Medicine and Biology·Chi LiuPaul E Kinahan
Feb 11, 2010·Nuclear Medicine Communications·Sona BalogovaJean-Noël Talbot
Apr 5, 2011·European Journal of Radiology·Valentina AmbrosiniStefano Fanti
Apr 22, 2011·Journal of Thoracic Imaging·Ho Yun Lee, Kyung Soo Lee
Dec 19, 2012·The Journal of Thoracic and Cardiovascular Surgery·Yasuhiro TsutaniMorihito Okada
Jun 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y TsutaniM Okada
Jan 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Satoshi TakeuchiHomer A Macapinlac
Jan 24, 2014·South Asian Journal of Cancer·Punit SharmaRakesh Kumar
Jun 26, 2014·The Annals of Thoracic Surgery·Shinsuke SasadaMorihito Okada
May 15, 2015·The Indian Journal of Radiology & Imaging·Archi Agrawal, Venkatesh Rangarajan
Jul 16, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Bruno HochheggerEdson Marchiori