The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer

BMC Cancer
Ching-Wen HuangJaw-Yuan Wang

Abstract

The epidermal growth factor receptor (EGFR)/RAS/RAF/MEK/MAPK pathway is an important pathway in the carcinogenesis, invasion and metastasis of colorectal cancers (CRCs). We conducted a retrospective study to determine the prognostic values of EGFR expression and KRAS mutation in patients with metastatic CRC (mCRC) based on synchronous or metachronous status. From October 2002 to March 2012, 205 patients with mCRC were retrospectively analyzed; 98 were found to have metachronous mCRC while 107 were found to have synchronous mCRC. The EGFR expressions were determinate by IHC (immunohistochemistry) analysis and categorized 1+ (weak intensity), 2+ (moderate intensity), and 3+ (strong intensity). Genomic DNA was isolated from frozen primary CRC tissues and direct sequencing of KRAS was performed. The clinicopathological features of these mCRC patients were retrospectively investigated according to EGFR expression and KRAS mutation status. Moreover, we analyzed the prognostic values of EGFR expression and KRAS mutation among these patients. Of the 205 patients with mCRC, EGFR expression was analyzed in 167 patients, and positive EGFR expression was noted in 140 of those patients (83.8%). KRAS mutation was investigated in 205 patients...Continue Reading

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Citations

Nov 25, 2014·BMC Cancer·Keigo MitsuiChoitsu Sakamoto
Mar 28, 2016·Critical Reviews in Oncology/hematology·Sally TemrazAli Shamseddine
Nov 12, 2015·Thoracic Cancer·Hongwei GuoJian Zhang
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Jun 6, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu-Chang LiuFei-Ting Hsu
Oct 5, 2016·Molecular Pharmaceutics·Max A KruzikiBenjamin J Hackel

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Statistical Package for the Social Sciences

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