The progress of targeted therapy in advanced gastric cancer

Biomarker Research
Miao-Zhen Qiu, Rui-Hua Xu

Abstract

Although palliative chemotherapy has been shown to prolong survival and improve quality of life, the survival of advanced gastric cancer (AGC) patients remains poor. With the advent of targeted therapy, many molecular targeted agents have been evaluated in clinical studies. Trastuzumab, an anti-HER2 monoclonal antibody, has shown activity against HER2-positive AGC and becomes the first targeted agent approved in AGC. Drugs that target epidermal growth factor receptor, including monoclonal antibody and tyrosine kinase inhibitor, do not bring survival benefit to patients with AGC. Additionally, vascular endothelial growth factor inhibitors are also under investigation. Ramucirumab has shown promising result. Other targeted agents are in preclinical or early clinical development, such as mammalian target of rapamycinm inhibitors and c-MET inhibitors.

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Jun 12, 2014·Drugs·Raewyn M Poole, Asha Vaidya
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Clinical Trials Mentioned

NCT01041404
NCT00486954
NCT00680901
NCT00678535
NCT01234324
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GRANITE
AVAGAST

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