The progressive response of the newborn infant to added respiratory loads.

Respiration Physiology
I D Frantz, J Milic-Emili

Abstract

The responses of 10 normal full-term infants to 10-sec airway occlusions at functional residual capacity were studied. The responses were quantified by measuring the pressure generated on successive inspiratory efforts following occlusions in room air and 100% oxygen. The response after oxygen breathing was 30-40% less than after air breathing, indicating that hypoxia accounted for part of the response. There was an increase in the response in air from the first to the fourth day of life. Endtidal carbon dioxide tension was shown to increase during the occlusion, but the response remaining after hypoxia was eliminated may not have been due entirely to hypercapnea. We conclude that the compensatory response of the infant to added respiratory loads is in part due to hypoxia, and that the hypoxic response increases over the first week of life.

References

Mar 1, 1975·Respiration Physiology·W A WhitelawJ Milic-Emili
Sep 1, 1973·Respiration Physiology·C E MargariaJ Milic-Emili
Aug 1, 1964·The Journal of Physiology·E J CAMPBELLJ B HOWELL

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Citations

Sep 1, 1981·Respiration Physiology·I R MossE M Scarpelli
Oct 6, 1977·The New England Journal of Medicine·M E Avery, I D Frantz
Dec 1, 1983·The Journal of Pediatrics·J V ArandaG Watters
Nov 25, 2000·Journal of Applied Physiology·G W DonK A Waters
Mar 16, 2005·Revue des maladies respiratoires·S MateckiUNKNOWN EFR pédiatriques de la Société de Physiologie

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