The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats

Experimental Neurology
Tarek HabashPaul Fernyhough

Abstract

Diabetic neuropathy comprises dying back of nerve endings that reflects impairment in axonal plasticity and regenerative nerve growth. Metabolic changes in diabetes can lead to a dysregulation of hormonal mediators, such as cytokines, that may constrain distal nerve fiber growth. Interleukin-17 (IL-17A), a proinflammatory and neurotropic cytokine produced by T-cells, was significantly reduced in sciatic nerve of streptozotocin (STZ)-diabetic rats. Thus we studied the effect of IL-17A on the phenotype of sensory neurons derived from age matched control or type 1 diabetic rats. The aims were to determine the ability of IL-17A to enhance neurite outgrowth in cultured sensory neurons, investigate the signaling pathways activated by IL-17A, study the role of mitochondria and mechanistically link to neurite outgrowth. IL-17A (10 ng/ml; p<0.05) significantly and dose-dependently increased total neurite outgrowth in cultures of adult dorsal root ganglia (DRG) sensory neurons derived from both control and streptozotocin (STZ)-diabetic rats. This enhancement was mediated by IL-17A-dependent activation of extracellular-regulated protein kinase (ERK) and phosphoinositide-3 kinase (PI-3K) signal transduction pathways. Pharmacological blocka...Continue Reading

References

Jan 1, 1992·Molecular Neurobiology·B W Bernstein, J R Bamburg
Sep 18, 1997·Journal of Neuropathology and Experimental Neurology·R E SchmidtK A Roth
Dec 18, 2002·Annals of the New York Academy of Sciences·Tertia D Purves, David R Tomlinson
Mar 6, 2003·Experimental Neurology·Julie A ChristiansonDouglas E Wright
Mar 26, 2003·Cytokine & Growth Factor Reviews·T A MoseleyA H Reddi
Mar 20, 2004·Journal of Neurochemistry·Mariana AlonsoJuan J Poderoso
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
May 9, 2006·Osteoarthritis and Cartilage·M J López-ArmadaF J Blanco
Jan 24, 2007·Acta Neuropathologica·Andrew P MizisinG Diane Shelton
Jan 29, 2008·Current Drug Targets·Nigel A CalcuttPaul Fernyhough
Nov 20, 2008·Journal of Neuropathology and Experimental Neurology·Robert E SchmidtKaren G Green
Feb 25, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Budd A Tucker, Karen M Mearow
Sep 11, 2009·The Biochemical Journal·Bradford G HillVictor M Darley-Usmar
Mar 23, 2010·Cell·Dan R Littman, Alexander Y Rudensky
Oct 5, 2010·The Journal of Pain : Official Journal of the American Pain Society·Cristina Fabiola Kim, Gila Moalem-Taylor
Mar 2, 2011·The American Journal of Pathology·Zhijie LiC Wayne Smith
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Marie Cargnello, Philippe P Roux
Apr 16, 2011·Trends in Immunology·Jarod ZeppXiaoxia Li
May 3, 2011·Trends in Biochemical Sciences·Michelle C MendozaJohn Blenis
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuhiko OhnoBruce D Trapp
Jul 6, 2011·The Biochemical Journal·Martin D Brand, David G Nicholls
Aug 20, 2011·Current Opinion in Immunology·Sarah L Gaffen
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan P ChisholmAlan E Lomax
Mar 27, 2012·Neurobiology of Disease·Subir K Roy ChowdhuryPaul Fernyhough

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Citations

Jul 18, 2016·Schizophrenia Research·Maiara Zeni-GraiffElisa Brietzke
Jan 31, 2017·Nature Reviews. Neurology·Nádia P GonçalvesTroels S Jensen
Aug 16, 2018·Physiological Reviews·Colin ReardonAlan E Lomax
Jun 30, 2019·Journal of Molecular Neuroscience : MN·Matanel Tfilin, Gadi Turgeman
Sep 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Ki-Joong KimChung Sik Cho
Dec 15, 2020·Diabetes & Metabolism Journal·Heung Yong JinNigel A Calcutt

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