The proinflammatory phenotype of senescent cells: the p53-mediated ICAM-1 expression

Annals of the New York Academy of Sciences
Dimitris KletsasVassilis G Gorgoulis

Abstract

Senescent cells are characterized by the activation of the tumor suppressor protein p53 and consequently their inability to proliferate. However, their phenotype is not restricted to the exhaustion of their replicative potential, as they also exhibit a proinflammatory phenotype, which could possibly contribute to the aging process. Intercellular adhesion molecule-1 (ICAM-1) is one of the molecules involved in inflammatory response that is overexpressed in senescent cells and aged tissues. Although the role of the nuclear factor-kappa B (NF-kappa B) signaling cascade is crucial in ICAM-1 activation, we have shown that p53 directly activates the expression of ICAM-1 in an NF-kappa B-independent manner. This may link p53 to ICAM-1 function and consequently to the aging process and to various age-related pathologies.

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Citations

Mar 4, 2009·Biogerontology·Thore C BrinkJames Adjaye
Feb 24, 2009·Age·D G A Burton
Apr 23, 2009·Critical Care Medicine·Basilia ZingarelliAlex B Lentsch
Jul 14, 2007·FEBS Letters·Kazutetsu Aoshiba, Atsushi Nagai
Mar 29, 2011·Journal of Theoretical Biology·Jacques DemongeotFlorence Thuderoz
Sep 13, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhihui YangAlexander Kabanov
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Sonja TextorAdelheid Cerwenka
Jul 31, 2010·Cell Biochemistry and Function·Young-Hee LeeHo-Keun Yi
Nov 12, 2009·International Journal of Cancer. Journal International Du Cancer·Krzysztof KsiazekJanusz Witowski
Jul 11, 2006·Brain, Behavior, and Immunity·Jose Javier Miguel-HidalgoGrazyna Rajkowska
May 25, 2013·Annals of Medicine·Runyi A LamStephan Gasser
Jul 1, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Maria Rosa GhignaKatrien Grünberg
May 8, 2021·Biotechnology Advances·Charlotte MaillotEric Olmos

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