The projections of the retrorubral field A8 to the hippocampal formation in the rat

Experimental Brain Research
A GasbarriV Perciavalle

Abstract

The dopaminergic neurons in the midbrain of the rat are located in three groups: the ventral tegmental area (VTA-A10), substantia nigra (SN-A9), and retrorubral field (RRF-A8). We have recently examined the organization of the projections from the VTA and the SN to the hippocampal formation (HF) in the rat. In the present study we characterize the projections of the RRF to the HF by using anterograde tracing, retrograde tracers, and tyrosine hydroxylase (TH) immunohistochemistry. Following iontophoretical injections of Phaseolous vulgaris leucoagglutinin (PHA-L) into the RRF, anterograde labeling was observed primarily in the ipsilateral subiculum and adjacent CA1 cell field. Sparse labeling was also observed in the CA3 cell field and dentate gyrus. The distribution of RRF neurons projecting to the HF was examined by injecting retrograde fluorescent tracers (fluorogold, fast blue, and nuclear yellow) into several hippocampal areas. The retrograde tracer findings indicate that the medial aspects of the RRF project to the subiculum and adjacent CA1 cell field of both the septal and temporal HF. In order to evaluate the percentage of dopaminergic cells of the RRF projecting to the HF, the retrograde neuronal tracer fluorogold was ...Continue Reading

Citations

Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·A GasbarriM G Packard
Jul 12, 2005·Journal of Neurotrauma·S W ScheffC Brackney
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos A Mejías-AponteGary Aston-Jones
Oct 4, 2015·FEBS Letters·Gabriela O Bodea, Sandra Blaess
Oct 20, 2006·Neuropharmacology·Katsunori Kobayashi, Hidenori Suzuki
Jan 28, 2014·Hippocampus·Madhusudhanan M KeralapurathJohn J Wagner
Jan 16, 2014·The Journal of Comparative Neurology·Günter U HöglingerWolfgang H Oertel
Feb 4, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Teodoro ZornozaLuis Granero
May 13, 2005·Journal of Neurophysiology·Nonna A OtmakhovaJohn E Lisman
Mar 24, 2021·Current Biology : CB·Mahsa Moaddab, Michael A McDannald

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