The prokineticin system: an interface between neural inflammation and pain

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Silvia FranchiAlberto E Panerai

Abstract

Prokineticins (PK) 1 and 2 belong to a new family of chemokines capable to interact with two different G coupled receptors: Prokineticin receptor (PKR)1 and 2. Both prokineticins and their receptors are widely distributed in different tissues and regulate several biological functions. In particular, a role of the PK system in inflammation and nociception has been established. PKRs are expressed in regions of the nervous system associated with pain and in primary sensitive neurons they colocalize with transient potential receptor vanilloid-TRPV1 providing an anatomical interaction in nociceptor sensitization. Moreover, PKs are strongly upregulated in immune and glial cells and sustain a proinflammatory loop in inflamed tissues. Recent evidences indicate that the block of the PK system represents a promising strategy to contrast inflammation and pain.

References

Dec 6, 2002·British Journal of Pharmacology·Lucia NegriPietro Melchiorri
Apr 7, 2004·British Journal of Pharmacology·Lucia NegriPietro Melchiorri
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer LeCouterNapoleone Ferrara
May 24, 2005·Journal of Leukocyte Biology·Marion DorschChristopher C Fraser
Nov 22, 2005·British Journal of Pharmacology·Cataldo MartucciPaola Sacerdote
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vittorio VellaniPeter A McNaughton
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisa GianniniLucia Negri
Aug 31, 2010·Neuropharmacology·Yan-Cai XiongWang-Ping Hu
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alberto E Panerai
Dec 2, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F GuidaL Luongo
Feb 3, 2015·Basic & Clinical Pharmacology & Toxicology·Li-Hua HangDong-Hua Shao
Apr 18, 2015·Neurology. Neuroimmunology and Neuroinflammation·Mhamad Abou-HamdanRosetta Pedotti
Feb 26, 2016·European Journal of Pain : EJP·T HoffmannP W Reeh
Sep 10, 2016·BMC Musculoskeletal Disorders·Haruyasu ItoDaitaro Kurosaka
Nov 27, 2016·EBioMedicine·Xiaoqin HeRen Lai

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Citations

Sep 10, 2020·Journal of Molecular Neuroscience : MN·Xian DingDongxiao Huang
Feb 12, 2019·Cellular and Molecular Gastroenterology and Hepatology·Wilmarie Morales-Soto, Brian D Gulbransen

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