PMID: 9525833Apr 3, 1998Paper

The proliferative potential of the pilocytic astrocytoma: the relation between MIB-1 labeling and clinical and neuro-radiological follow-up

Journal of Neuro-oncology
C M DirvenW M Molenaar

Abstract

The proliferative potential of 39 pilocytic and 5 low grade astrocytomas was studied in relation to the Ki-67 activity as measured by the MIB-1 Labelings Index. The results were correlated to the biological behaviour of the tumor as measured by clinical and neuro-radiological (CT- or MRI-scans) follow-up of the patient. This study was undertaken to answer the question whether MIB-1 expression reflects differences in biological behaviour of these tumors, such as rapid progression of residual tumor or stable remaining tumor. MIB-1 LI values ranged from 0 to 19% in the group of pilocytic astrocytomas (mean 4.2%) and from 0 to 15% in the 5 low grade astrocytomas (mean 4,2%). All patients were operated and 23 of them had incomplete tumor resection as proven on postoperative neuro-imaging studies. Those 23 patients could be subdivided into two groups; one without progression of residual tumor during follow-up (n=12) and the other with tumor progression (n=11). mean MIB-1 LI in the group with 'quiescent' tumor tended to be lower than in the group with progressive tumor: 3,3% vs. 6,6%. Residual tumors which were negative for MIB-1 staining showed fewer progressions of residual tumor compared to those being positive for MIB-1 staining, ...Continue Reading

Citations

May 2, 2009·Brain Tumor Pathology·Ichiyo ShibaharaTeiji Tominaga
Mar 13, 2010·Neuro-oncology·Sarah Z RushMichael K Cooper
Oct 5, 2010·Journal of Neurosurgery. Pediatrics·Ian G DorwardJeffrey R Leonard
Apr 26, 2014·Ophthalmic Plastic and Reconstructive Surgery·Lora R Dagi GlassMichael Kazim
Nov 6, 2012·Annual Review of Pathology·Fausto J RodriguezCharles G Eberhart
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel C BowersLinda R Margraf
Aug 4, 2005·Journal of Neuro-oncology·Alfredo Quiñones-HinojosaMichael W McDermott
Jul 20, 2006·Journal of Neurosurgery·Ute BartelsEric Bouffet
Jul 28, 2005·Pediatric Radiology·Roxana S GunnyDawn E Saunders
Oct 17, 2009·Brain Pathology·Craig HorbinskiIan F Pollack
Jul 16, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Murat Şakir EkşiTürker Kılıç
Dec 8, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Michael VassilyadiEnrique Ventureyra
Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BredelJ A Hainfellner
Apr 20, 2006·Clinical Neurology and Neurosurgery·Mark K Lyons

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