PMID: 20646570Jul 22, 2010Paper

The proliferous rule of bile duct endothelium after the placement of metallic biliary stent:a study in canine

Zhonghua yi xue za zhi
Xiao-nan MaoZhao-yu Liu

Abstract

To discuss the proliferous rule of bile duct endothelium after the placement of metallic biliary stent. The metallic biliary stent was placed at the inferior segment of common bile duct of canine after a percutaneous transhepatic puncture at cholecyst. All the stented dogs were assigned randomly to 4 group including A, B, C and D, each group had been under research for 1 month, 3 months, 12 months and 24 months. The expression of PCNA and Ki-67 in bile duct endothelium covered by the stent were calculated on the immunohistochemistry staining images and compared with those uncovered in each group, then the expression of PCNA and Ki-67 in bile duct endothelium covered by the stent were compared between every two adjacent groups. The thickness of bile duct wall covered by the stent were measured on the HE staining images and compared between every two adjacent groups. The t-test was performed for the statistics. The animal model were successfully set in 18 canines. The expression of PCNA and Ki-67 in bile duct endothelium covered by the stent were significantly higher than those uncovered in every group (P < 0.05), which got much high within 1 month after stenting (P < 0.05) and gradually raised up again from 3 months to 1 year (P...Continue Reading

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