The promise and challenge toward the clinical application of maspin in cancer

Frontiers in Bioscience : a Journal and Virtual Library
Shijie Sheng

Abstract

Since the identification of the human maspin gene, a decade of extensive research revealed the promise of maspin both as a valuable molecular marker for the diagnosis and prognosis of many types of cancers, and as a tumor suppressor at the level of tumor growth, invasion, angiogenesis, metastasis, and tumor sensitivity to drug-induced apoptosis. This review is intended to summarize the consensus of these findings, and provide an overview of the current challenges toward the clinical application of maspin. Specifically, this review discusses several likely molecular mechanisms underlying (1) the differential regulation of maspin expression, and (2) the biological activities of maspin in tumor progression.

Citations

Aug 22, 2009·Journal of Oncology·Daris FerrariPaolo Foa
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhila Khalkhali-Ellis
Nov 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hui-hui ZhangLin Qi
May 22, 2008·Journal of Cellular Biochemistry·Zhila Khalkhali-EllisMary J C Hendrix
Jul 25, 2015·Cellular and Molecular Life Sciences : CMLS·Keigo ArakiKeiko Kawauchi
Nov 8, 2005·Gynecologic Oncology·H W Raymond LiYick Fu Wong
Sep 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fulvio LonardoShijie Sheng
Nov 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eiman Adel Hasby
Dec 6, 2005·Journal of Cellular Biochemistry·Jaron LockettShijie Sheng
Mar 21, 2007·Pigment Cell Research·Alexandra E DenkAnja K Bosserhoff
Sep 20, 2006·Cancer Research·Xiaohua LiShijie Sheng

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