Jun 19, 2007

The promise and peril of transcriptional profiling in biofilm communities

Current Opinion in Microbiology
Dingding An, Matthew R Parsek

Abstract

DNA microarray technology has been successfully used to identify genes that contribute to biofilm formation for a handful of bacterial species. However, as the number of profiling studies increases, it is becoming increasingly apparent that these data might miss important aspects of biofilm development. One reason for this is the inability of current experimental designs to resolve spatial and functional heterogeneity in the biofilm community. Thus, an emerging challenge is to use transcriptional profiling in combination with techniques that can identify and separate relevant subpopulations within a biofilm.

  • References33
  • Citations49

Citations

Mentioned in this Paper

Microorganism
Metabolic Process, Cellular
Gene Expression Regulation, Bacterial
Biological Adaptation to Stress
Adhesins, Bacterial
DNA Microarray Format
Vibrio cholerae
Extracellular
Cell Motility
Transcription, Genetic

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