PMID: 8939645Dec 1, 1996Paper

The promise and pitfalls of monoclonal antibody therapeutics

Current Opinion in Biotechnology
I Berkower

Abstract

Recent experience has helped to clarify the best ways to use monoclonal antibodies to solve clinical problems. For example, imaging based on tumor antigens, rather than tumor size, will permit early detection of cancer and accurate staging. Blocking receptor-ligand interactions may permit therapeutic intervention in cell growth or function but activity may depend on the choice of an antiligand or antireceptor strategy. Humanized antibodies will achieve greater intensity and duration of therapy, while allowing repeat administration in chronic diseases.

Citations

Sep 1, 2000·Advanced Drug Delivery Reviews·F NilssonD Neri
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Apr 25, 2000·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·L B Hurd, G R Lichtenstein
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