The promise of microarray technology in melanoma care

Cancer Control : Journal of the Moffitt Cancer Center
Christina J KimTimothy J Yeatman

Abstract

Genetic aberration is responsible for the development of neoplastic potential in a number of malignancies. These DNA alterations result in significant changes in gene expression that may now be measured and catalogued. The microarray technique screens and identifies expressed genes that may be responsible for tumorigenesis. The authors review the application of the microarray technique in malignant melanoma. Candidate melanoma suppressor genes have been identified in melanoma cell lines using this technique. Furthermore, molecular classification using gene expression profiling may improve the accuracy of the staging system for determining prognosis. The microarray technique is in its initial development for clinical application in a variety of tumor models. Melanoma is an ideal system to study the genetic changes associated with the stepwise progression of malignancy. It may be possible to efficiently screen the entire human genome to identify the particular aberrations in gene expression responsible for tumorigenesis in melanoma.

References

Oct 1, 1991·Trends in Genetics : TIG·G G Lennon, H Lehrach
Oct 20, 1995·Science·V E VelculescuK W Kinzler
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R A HellerR W Davis
Apr 10, 1999·Electrophoresis·J KhanP S Meltzer
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·S K LoftusW Pavan
Jul 8, 2000·Pigment Cell Research·S K Loftus, W J Pavan
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·M J HendrixR E Seftor

❮ Previous
Next ❯

Citations

Aug 12, 2003·Expert Review of Vaccines·Emina H Huang, Howard L Kaufman
Nov 19, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil Crowson
Mar 28, 2006·Journal of Cellular and Molecular Medicine·Elisabeth A SeftorMary J C Hendrix
Jun 5, 2003·Nature Reviews. Cancer·Mary J C HendrixRichard E B Seftor
Mar 26, 2009·Annals of Saudi Medicine·Nazar M T Jawhar
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas JohnJonathan S Cebon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of the American Dental Association
Trevor J PembertonPragna I Patel
Journal of Gastroenterology
Motoyuki OtsukaMasao Omata
DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes
Shivakumar KeerthikumarAkhilesh Pandey
Proceedings of the National Academy of Sciences of the United States of America
C KendziorskiM N Gould
© 2022 Meta ULC. All rights reserved