The promise of nanotechnology for heart, lung and blood diseases

Expert Opinion on Drug Delivery
Denis B Buxton

Abstract

Nanotechnology offers a broad range of opportunities for improving the diagnosis and therapy for heart, lung and blood diseases, and drug delivery represents an area of particular promise. For cardiovascular disease, the treatment of atherosclerotic plaque and prevention of restenosis following stent placement offer attractive targets for nanotechnology. In lung disease, nanotechnology may provide novel treatments for a broad range of intractable pulmonary diseases, including bacterial biofilms, fungal infections, and tuberculosis. For haematopoietic diseases, targeted delivery of drugs to lymphocytes may represent a strategy for reducing systemic cytotoxicity. This editorial discusses some of the more promising targets for nanotechnology-based treatment of heart, lung and blood diseases.

References

Mar 29, 2003·Circulation Research·Toyokazu UwatokuAkira Takeshita
Mar 12, 2005·The Journal of Antimicrobial Chemotherapy·Rajesh Pandey, G K Khuller
Mar 26, 2005·Immunology Letters·Xin WangMasaori Baba
Aug 4, 2005·Expert Review of Cardiovascular Therapy·Tillmann CyrusGregory M Lanza

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Citations

Jul 22, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey W CardEarle R Nestmann
Oct 25, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jakob LöndahlOtmar Schmid
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shelton D CaruthersGregory M Lanza
Nov 14, 2013·Pharmaceutical Development and Technology·Jaleh VarshosazMahboubeh Rostami

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