The Promise of Novel Biomarkers for Head and Neck Cancer from an Imaging Perspective

International Journal of Molecular Sciences
Loredana G MarcuEva Bezak

Abstract

It is an agreed fact that overall survival among head and neck cancer patients has increased over the last decade. Several factors however, are still held responsible for treatment failure requiring more in-depth evaluation. Among these, hypoxia and proliferation-specific parameters are the main culprits, along with the more recently researched cancer stem cells. This paper aims to present the latest developments in the field of biomarkers for hypoxia, stemness and tumour proliferation, from an imaging perspective that includes both Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) as well as functional magnetic resonance imaging (MRI). Quantitative imaging of biomarkers is a prerequisite for accurate treatment response assessment, bringing us closer to the highly needed personalised therapy.

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Citations

Dec 22, 2019·Stem Cell Reviews and Reports·Heena JariyalAkshay Srivastava
Nov 18, 2020·Journal of Personalized Medicine·Loredana G Marcu
Feb 27, 2021·ANZ Journal of Surgery·Norhafiza Mat LazimJonathan Clark
Oct 15, 2020·Physics in Medicine and Biology·S C M Ten EikelderR Jeraj

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Methods Mentioned

BETA
imaging techniques
biopsy
xenografts

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