The Promise of Preventive Cancer Vaccines

Vaccines
Pier-Luigi LolliniElena Quaglino

Abstract

Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities. These considerations summed with the increased understanding of tumor antigens allow space for an optimistic view of the future.

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Aug 8, 2019·Expert Opinion on Drug Delivery·Kenneth Lundstrom
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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT00107211
NCT00773097
NCT02134925
NCT01431391
NCT00639639
NCT00524277
NCT00841399
NCT00854789
NCT01479244
NCT01510288

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