The promise of proprotein convertase subtilisin/kexin 9 inhibitors for the treatment of familial hypercholesterolemia

Current Atherosclerosis Reports
Yashashwi PokharelChristie M Ballantyne

Abstract

Familial hypercholesterolemia comprises a constellation of genetic disorders resulting in very high cholesterol levels since childhood. If untreated, it is associated with accelerated atherosclerosis and premature cardiovascular disease. It has been shown that if aggressive cholesterol lowering is achieved in familial hypercholesterolemia, the incidence of cardiovascular disease can be lowered. However, currently approved pharmacological therapies are not able to lower cholesterol to optimal levels in a large number of these patients. Proprotein convertase subtilisin/kexin 9 inhibitors are a new class of cholesterol-lowering medications that can significantly reduce cholesterol levels in these patients especially those with at least some functioning low-density lipoprotein receptors. In this article, we will briefly review familial hypercholesterolemia and the role of proprotein convertase subtilisin/kexin 9 inhibitors in this condition.

References

Jan 1, 1979·Annual Review of Genetics·J L Goldstein, M S Brown
Jan 1, 1985·Annual Review of Cell Biology·J L GoldsteinW J Schneider
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G ZulianiR Fellin
Jul 3, 2002·The Journal of Clinical Investigation·Clive R PullingerJohn P Kane
May 6, 2003·Nature Genetics·Marianne AbifadelCatherine Boileau
Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kara N MaxwellJan L Breslow
Apr 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shirya RashidJay D Horton
Mar 24, 2006·The New England Journal of Medicine·Jonathan C CohenHelen H Hobbs
Nov 3, 2006·The Journal of Clinical Investigation·Thomas A LagaceJay D Horton
May 24, 2008·The New England Journal of Medicine·Sekar Kathiresan, UNKNOWN Myocardial Infarction Genetics Consortium
Jun 24, 2008·Journal of Cellular Physiology·Trine RanheimTrond P Leren
Aug 5, 2008·Biochemical and Biophysical Research Communications·LiXin ShanJoseph A Hedrick
Aug 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria Frank-KamenetskyKevin Fitzgerald
Nov 13, 2008·BMJ : British Medical Journal·Jorie VersmissenEric J G Sijbrands
Jun 3, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick LabontéNabil G Seidah
Jun 29, 2010·Journal of the American College of Cardiology·Marianne BennAnne Tybjaerg-Hansen
May 27, 2011·Journal of Clinical Lipidology·Paul N HopkinsUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Mar 23, 2012·The New England Journal of Medicine·Evan A SteinGary D Swergold
Jul 20, 2012·Journal of Lipid Research·Gilles LambertG Kees Hovingh
Nov 2, 2012·The New England Journal of Medicine·Eli M RothEvan A Stein
Feb 5, 2013·The American Journal of Cardiology·John C LaRosaScott M Wasserman
Nov 15, 2013·The Journal of Biological Chemistry·Yingnan ZhangDaniel Kirchhofer
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Jun 25, 2014·Nature Reviews. Cardiology·Razvan T Dadu, Christie M Ballantyne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Li ShenShuiping Zhao
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
Ahmet AvciBülent Behlül Altunkeser
Medsurg Nursing : Official Journal of the Academy of Medical-Surgical Nurses
Mary B Engler
© 2021 Meta ULC. All rights reserved