The promise of using personalized genomic information to promote behavior change: is the debate over, or just beginning?

Personalized Medicine
Kristi D GravesSuzanne C O'Neill

Abstract

Over recent years, significant debate has centered on whether and how communication of personalized genomic risk information can positively influence health behavior change. Several thoughtful commentaries have cautioned that efforts to incorporate genomic risk feedback to motivate health behavior change have had little success. As a field, we should consider the reasons for this limited success and be strategic in the next steps for this line of research. In this article, we consider several reasons that prior research that integrates personalized genomic information has had relative degrees of success in changing or maintaining health behaviors. We suggest ways forward and outline the possibilities presented by emerging technologies and novel approaches in translational genomic research.

References

Jan 1, 1992·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·N D Weinstein, P M Sandman
Oct 3, 2002·Journal of Health Communication·Jay M BernhardtElizabeth M Felter
Nov 1, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T R Rebbeck
Jan 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Muin J KhouryW Dana Flanders
Mar 11, 2005·Health Affairs·Cathleen D ZickRobert C Green
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jonine L BernsteinPatrick Concannon
Sep 19, 2006·Journal of Medical Systems·Daniel P LorenceSusannah Fox
Nov 23, 2006·JAMA : the Journal of the American Medical Association·Chris Carlsten, Wylie Burke
Feb 13, 2007·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Matthew J CarpenterGregory E Gilbert
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining Chen, Giovanni Parmigiani
Oct 12, 2007·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Stephanie JilcottRussell E Glasgow
Dec 7, 2007·Obstetrics and Gynecology·Kathy HudsonUNKNOWN American Society of Human Genetics Social Issues Committee
Feb 9, 2008·Health Informatics Journal·Daniel Lorence, Heeyoung Park
Mar 5, 2008·Alzheimer Disease and Associated Disorders·Serena ChaoRobert C Green
Apr 17, 2008·Nature Reviews. Genetics·Morris W Foster, Richard R Sharp
Apr 18, 2008·Community Genetics·Rosalina D JamesUNKNOWN Health Disparities Working Group
Sep 5, 2008·Annual Review of Genomics and Human Genetics·Stuart HogarthDavid Melzer
Sep 23, 2008·Journal of Behavioral Medicine·Shoshana ShilohEitan Friedman
Dec 11, 2008·JAMA : the Journal of the American Medical Association·Amy L McGuire, Wylie Burke
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
May 30, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Morris W FosterRichard R Sharp
Jul 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Saskia C SandersonColleen M McBride
Jul 17, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Colleen M McBrideLawrence C Brody
Jul 23, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Scott D GrosseMuin J Khoury
Aug 7, 2009·Journal of Neural Transmission·Andrea M DlugosHarriet de Wit
Aug 8, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·D Gareth R EvansAnthony Howell
Aug 15, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Katherine KolorMuin J Khoury
Sep 16, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sandra Suther, Gebre-Egziabher Kiros
Dec 1, 2009·American Journal of Preventive Medicine·José A PagánDavid A Asch
Jan 6, 2010·Health Affairs·Donald H TaylorRobert C Green
Jan 23, 2010·Clinical Genetics·C M Condit
Mar 6, 2010·Psychology & Health·Kate Sweeny, James Shepperd
Mar 12, 2010·The American Journal of Clinical Nutrition·Jacqueline A VernarelliRobert C Green
Mar 25, 2010·JAMA : the Journal of the American Medical Association·Silvia StringhiniArchana Singh-Manoux
Apr 13, 2010·Breast Cancer Research and Treatment·Suzanne C O'NeillMarc D Schwartz
Apr 29, 2010·Genome Medicine·Helena FurbergPatrick F Sullivan
May 4, 2010·Lancet·Euan A AshleyRuss B Altman
Jun 10, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Suzanne C O'NeillKimberly A Kaphingst
Jul 24, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Christian S HendershotTamara L Wall
Aug 19, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Cinnamon S BlossEric J Topol
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
Oct 6, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Claire Julian-ReynierCatherine Nogués
Jan 14, 2011·The New England Journal of Medicine·Cinnamon S BlossEric J Topol
Jan 19, 2011·Annals of Family Medicine·Mack T RuffinUNKNOWN Family History Impact Trial (FHITr) Group

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Citations

Dec 8, 2016·Journal of Community Genetics·Vivian M RodríguezJennifer L Hay
Dec 12, 2017·Social and Personality Psychology Compass·Linda D CameronWilliam M P Klein
Feb 1, 2018·Translational Behavioral Medicine·Alex T RamseyLaura J Bierut
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Emily OlfsonUNKNOWN PGen Study Group
Dec 17, 2017·Cancer Prevention Research·Peter A Kanetsky, Jennifer L Hay
May 22, 2016·Neuroscience Letters·Li-Shiun ChenLaura Bierut

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