The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury

The Journal of Craniofacial Surgery
Lifeng QiBaoliang Sun

Abstract

Many studies have reported the recovery ability of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neonatal rat umbilical cord immediately after delivery. The traumatic brain injury (TBI) model was formed by the classical gravity method. The authors detected the behavior changes and measured the levels of inflammatory factors, such as interleukin-lβ and tumor necrosis factor-α by enzyme linked immunosorbent assay (ELISA) at 1, 2, 3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. Simultaneously, the expression of glial cell line-derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) were measured by real-time-polymerase chain reaction and ELISA.The authors found that the group of transplantation UC-MSCs has a significant improvement than other group treated by phosphate buffered saline. In the behavioral test, the Neurological Severity Scores of UC-MSCs + TBI group were lower than TBI group (P < 0.05), but not obviously higher than control group at 2, 3, and 4week, respectively. Th...Continue Reading

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Citations

Jan 4, 2020·Journal of Molecular Neuroscience : MN·Fatemeh DehghanianMohammad Khaksari
Feb 26, 2020·Pharmaceuticals·Andreia G PinhoAntónio J Salgado
Jun 11, 2020·International Journal of Molecular Sciences·Rami Ahmad ShahrorKai-Yun Chen
Jan 10, 2021·Stem Cell Reviews and Reports·Lacy E LowryJames A Bynum
Apr 4, 2021·International Journal of Molecular Sciences·David GustafssonElham Rostami
Apr 16, 2021·Advanced Science·Anna AndrzejewskaMiroslaw Janowski

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Methods Mentioned

BETA
Flow Cytometry
Enzyme
PCR
enzyme linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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