The Promising Role of Probiotics in Managing the Altered Gut in Autism Spectrum Disorders.

International Journal of Molecular Sciences
Basma AbdellatifAli Chaari

Abstract

Gastrointestinal symptoms (GIS) have been reported repeatedly in people with autism spectrum disorder (ASD) and studies have reported interesting correlations between severity of behavioral and gastrointestinal symptoms. Growing evidence indicates that the gut microbiota in ASD is altered with various shifts described at different taxonomic levels, pointing to the importance of considering the gut-brain axis in treatment of these disorders. Probiotics are live beneficial bacteria that are ingested as food or customized pills. These beneficial bacteria, when added in sufficient amounts, can correct the dysbiosis. Because probiotics have shown success in treating irritable bowel syndrome (IBS), it is plausible to investigate whether they can induce alleviation of behavioral symptoms as well. Probiotics show, in some clinical studies, their potential benefits (1) in improving gastrointestinal dysfunction, (2) in correcting dysbiosis, (3) in consequently reducing the severity of ASD symptoms. This review compiles data from selected studies that investigate these benefits and the mechanisms that mediate these effects, which include the production of metabolites, hormones, and neurotransmitters and the regulation of pro-inflammatory ...Continue Reading

References

Aug 2, 2000·Journal of Child Neurology·R H SandlerH M Wexler
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T PessiE Isolauri
Feb 7, 2001·The American Journal of Clinical Nutrition·P R MarteauJ Schrezenmeir
Jun 5, 2002·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Sep 7, 2002·The British Journal of Nutrition·L J Fooks, G R Gibson
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Jean FioramontiLionel Bueno
Feb 24, 2006·Journal of Molecular Microbiology and Biotechnology·Milton H Saier, Nahla M Mansour
May 11, 2006·Journal of Developmental and Behavioral Pediatrics : JDBP·Maria Valicenti-McDermottShlomo Shinnar
Jul 26, 2006·The American Journal of Gastroenterology·Peter J WhorwellEamonn M M Quigley
Aug 3, 2006·Pediatrics·John PendersEllen E Stobberingh
Dec 8, 2006·European Journal of Clinical Nutrition·D BentonA Brown
Jan 9, 2007·Journal of Neuroinflammation·Marvin BorisDouglas L Feinstein
Apr 13, 2007·Brain, Behavior, and Immunity·Lisa E GoehlerRonald P A Gaykema
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
May 6, 2008·Journal of Psychiatric Research·Lieve DesbonnetTimothy G Dinan
Jul 9, 2008·Journal of Pediatric Gastroenterology and Nutrition·Pinaki PanigrahiIra H Gewolb
Sep 16, 2008·Journal of Autism and Developmental Disorders·Roumen N NikolovLawrence Scahill
Feb 17, 2009·Pediatric Research·Eric Fombonne
Mar 12, 2009·The American Journal of Gastroenterology·Darren M BrennerPhilip S Schoenfeld
Mar 27, 2009·Brain : a Journal of Neurology·Jorge CorrealeMaría Inés Gaitán
May 1, 2009·Nature Reviews. Gastroenterology & Hepatology·Sang H RheeEmeran A Mayer
Jul 21, 2009·Current Gastroenterology Reports·Franklin Tsai, Walter J Coyle
Jul 7, 2010·Anaerobe·Sydney M FinegoldJohn A Green
Jul 14, 2010·Nature Reviews. Microbiology·Sandra NellChristine Josenhans
Jul 29, 2010·BMC Complementary and Alternative Medicine·Wibke GrossThomas Ostermann
Aug 10, 2010·Biochimica Et Biophysica Acta·Sa'ad H Al-LahhamKoen Venema
Aug 21, 2010·Journal of Medical Microbiology·Teresa J StradomskaDanuta Dzierzanowska
Aug 28, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuying LiuJon Marc Rhoads

❮ Previous
Next ❯

Citations

Dec 31, 2020·International Journal of Molecular Sciences·Yuanpeng ZhengAletta D Kraneveld
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Shoshana EitanJacob Kuempel
Jul 3, 2021·International Journal of Molecular Sciences·Enrico PracucciSilvia Landi

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
biopsies
PCR

Software Mentioned

Scopus
Google Scholar

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Nutrients
Antonella FattorussoSusanna Esposito
Medizinische Monatsschrift für Pharmazeuten
Heinrich Konrad Geiss
Journal of Primary Health Care
Shane L Scahill
© 2022 Meta ULC. All rights reserved