PMID: 8584674Jan 1, 1995Paper

The promoter of the human monoamine oxidase A gene

Progress in Brain Research
R M Denney

Abstract

Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Evidence that MAO A deficient males in a large Dutch kindred suffer from mild mental retardation and occasional episodes of impulsive-aggressive behavior makes it important to understand how the human MAO A promoter is regulated. Workers in multiple laboratories have isolated and characterized protein-coding sequences of the human MAO A gene and the DNA region where mRNA synthesis is initiated. After summarizing our published findings concerning where transcription of the human MAO A gene is initiated, I summarize representative results of transient expression assays aimed at assessing whether some potential gene regulatory agents affect the expression of luciferase from MAO A promoter reporter constructs when transfected into a mouse L cell line which expresses MAO A. These studies revealed no specific regulatory effects of serum, dexamethasone or a stable cyclic-AMP analogue on the human MAO A promoter introduced.

Citations

Jun 6, 2003·Journal of Neurophysiology·Frank RichterHans-Georg Schaible
Jun 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irini ManoliMarc R Blackman
May 25, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen M JohnsonDavid J Majewski
Nov 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kamon IigayaHiroshi Itoh

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