The promoter-proximal region of the Bacillus licheniformis penicillinase gene: Nucleotide sequence and predicted leader peptide sequence

Gene
J Kroyer, S Chang

Abstract

Penicillinase (beta-lactamase) is a major species of secreted protein produced by Bacillus licheniformis 749. From the pTB2 recombinant plasmid containing the cloned entire penicillinase (penP) gene, we have isolated and sequenced a 446-bp HpaII fragment carrying the beginning of penP. The 3'-end coding region of 216-bp on this DNA fragment codes for the first 72 amino acids of the prepenicillinase protein. The deduced structure of the leader peptide consists of a 34 amino acid signal sequence with a hydrophilic N-terminal region and a central hydrophobic core.

References

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Citations

Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S LöfdahlM Lindberg
Jan 1, 1984·Biotechnology & Genetic Engineering Reviews·R H Doi
Jul 10, 1982·Nucleic Acids Research·J R McLaughlinS Chang
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Apr 1, 1982·Archives of Biochemistry and Biophysics·R H Doi
Jun 1, 1986·Journal of Bacteriology·A J Salerno, J O Lampen

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