The propagation of induced tendon lesions in the equine superficial digital flexor tendon: an ex vivo study

Equine Veterinary Journal
G BoschP R van Weeren

Abstract

Clinical tendon lesions usually enlarge during the first days to weeks after sustaining the injury due to enzymatic and biomechanical influences. Limiting this enlargement would positively influence prognosis related to lesion size. To investigate the effect of cyclic loading on the propagation of enzymatically and physically induced tendon lesions and to assess the effect of immobilisation thereon in an ex vivo model. Equine cadaver limbs with either physically or collagenase-induced SDFT lesions were placed in a pneumatic loading device. Groups consisted of unloaded limbs, cyclically loaded limbs and cyclically loaded limbs with fibreglass cast immobilisation. Lesion size was evaluated ultrasonographically and macroscopically and load at failure was determined for groups where lesions enlarged. Physically induced lesions did not propagate after cyclical loading and were not further investigated. Collagenase-induced lesions propagated significantly more after cyclical loading compared to unloaded limbs. This propagation could effectively be reduced by immobilisation through a lower limb cast. Immobilisation did not influence load at failure. The combination of enzymatic and mechanical stimulation caused the lesions to propagat...Continue Reading

References

Jan 1, 1978·Connective Tissue Research·J KastelicE Baer
Jan 1, 1986·Journal of Biomechanics·S L WooW H Akeson
Jan 19, 1985·The Veterinary Record·P D RossdaleK offord
Jan 1, 1982·Journal of Biomechanics·D J Riemersa, H C Schamhardt
Mar 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A Buckwalter
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Y NabeshimaJ H Herman
Sep 2, 1998·Journal of Structural Biology·P FratzlS Bernstorff
Aug 5, 2000·Foot & Ankle International·S G PneumaticosS G Trevino
Oct 19, 2000·Equine Veterinary Journal·B A DowlingR K Smith
Nov 21, 2000·Scandinavian Journal of Medicine & Science in Sports·P Kannus
Mar 2, 2002·Journal of Biomechanical Engineering·Ei YamamotoKozaburo Hayashi
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Linda A DahlgrenAlan J Nixon
Nov 29, 2002·Equine Veterinary Journal·R K W SmithA M Wilson
Dec 18, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R K W SmithA E Goodship
May 20, 2003·Scandinavian Journal of Medicine & Science in Sports·P KannusM Järvinen
Feb 25, 2006·Acta Physiologica·F PoelkensM T E Hopman
Apr 11, 2006·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Christopher J MehalloJeffrey R Bytomski
Aug 19, 2007·International Journal of Experimental Pathology·Peter D CleggRoger K Smith
Mar 18, 2008·The Journal of Hand Surgery·Kieran M HirparaMichael E O'Sullivan

❮ Previous
Next ❯

Citations

Aug 29, 2012·American Journal of Veterinary Research·Stuart A VallanceLarry D Galuppo
Oct 19, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jeffrey T SpangAndreas B Imhoff
Nov 18, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Elizaveta KonMaurilio Marcacci
Aug 15, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Johannes L TolNicola Maffulli
Sep 13, 2016·Osteoarthritis and Cartilage·P M van der Kraan
Oct 27, 2020·Frontiers in Veterinary Science·Mathilde PluimCathérine Delesalle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.