PMID: 8593088Jun 1, 1995Paper

The property of tetracyclines to induce methemoglobin formation in erythrocytes and to inactivate catalase when exposed to radiation in the visible range

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
Iu M PetrenkoIu A Vladimirov

Abstract

When tetracycline and chlortetracycline were incubated an a dark room in the presence of erythrocytes with erythrocytic catalase completely inactivated by sodium azide, the antibiotics induced methemoglobin formation in them. If the catalase was not inactivated, no such phenomenon was observed. This meant that after the penetration into the erythrocytes the tetracyclines induced in them the generation of hydrogen peroxide which was the immediate cause of the methemoglobin formation. The effect of the methemoglobin formation on the erythrocytes was also induced by tetracycline without the catalase blocking when the erythrocytes were exposed to the antibiotic and visible light. The effect was not mediated by the hydrogen peroxide action on hemoglobin in the erythrocytes as it was in the previous case, since even when catalase was added exogenously to the suspension medium it induced no suppression of the methemoglobin formation in the erythrocytes. Additional introduction of exogenous catalase to the erythrocyte hemolysates prior to the exposure did not either influence the methemoglobin formation photoinduced in them by tetracycline. The effect manifestation was not practically influenced by L-histidine, mannitol or ethanol used...Continue Reading

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