The prophylactic conversion to an extended infusion schedule and use of premedication to prevent hypersensitivity reactions in ovarian cancer patients during carboplatin retreatment.

Gynecologic Oncology
Roisin O'CearbhaillPaul Sabbatini

Abstract

Repeated exposure to carboplatin can lead to hypersensitivity reactions during retreatment with carboplatin. This may prevent its further use in platinum-sensitive ovarian cancer patients. At our institution, an increasing proportion of patients are prophylactically converted to an extended schedule of infusion after 8 cycles of carboplatin. We sought to determine whether an incrementally increasing, extended 3-hour infusion of carboplatin with appropriate premedication was associated with a lower rate of hypersensitivity reactions compared to the standard 30-minute schedule in sequentially treated patients. We performed a retrospective electronic medical record review of patients with recurrent ovarian cancer retreated with carboplatin at our institution from January 1998 to December 2008. Seven hundred and seventy-seven patients with relapsed ovarian, fallopian tube, or primary peritoneal cancer were retreated with carboplatin and met study inclusion criteria. Of these, 117 (17%) developed hypersensitivity reactions during second-line or greater carboplatin-based treatment for recurrent disease. Only 6 (3.4%) of the 174 patients who received the extended schedule developed hypersensitivity reactions (0% grade 4; 50% grade 3) ...Continue Reading

References

Mar 1, 1976·Clinical Allergy·M J CleareJ Pepys
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·A H CalvertK R Harrap
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J S MorganM D Mason
Jan 29, 2002·Gynecologic Oncology·Maurie Markman
Aug 7, 2003·Seminars in Radiation Oncology·Andy TrottiPhilip Rubin
Apr 15, 2005·Journal of Chemotherapy·M P ZorzouA Bamias
Jun 27, 2006·Gynecologic Oncology·Marisa NavoJudith A Smith
May 27, 2008·The Journal of Allergy and Clinical Immunology·Mariana C CastellsUrsula A Matulonis
Aug 30, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GadducciA R Genazzani
Jun 9, 2009·The Journal of Allergy and Clinical Immunology·Paul E HesterbergJohnson T Wong

❮ Previous
Next ❯

Citations

Nov 15, 2013·Future Oncology·Antonio González
Jul 10, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Avinash PandeyJyoti Bajpai
Oct 5, 2010·Metal-based Drugs·Nektaria MakriliaMuhammad Wasif Saif
Dec 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D LorussoG Ferrandina
Jun 10, 2015·Japanese Journal of Clinical Oncology·Shingo MiyamotoKazumichi Ando
Oct 25, 2016·Cancer Treatment Reviews·Bradley J MonkMaurizio D'Incalci
Jan 27, 2017·International Journal of Clinical Oncology·Yuki KawaradaKiyofumi Yamada
Oct 13, 2017·Future Oncology·Andrés Poveda, Christian Marth
Oct 12, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Peter G RoseNicolas Link
Sep 3, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A LiuM Castells
Sep 21, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alice BergaminiGiorgia Mangili
Mar 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tingting Sun, Lei Li
Nov 20, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Katarzyna J JerzakHelen J Mackay
May 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Katherine LaVigneRoisin E OʼCearbhaill
Oct 10, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·M P LythgoeL Tookman
Sep 11, 2021·Cancer Medicine·Nobuyuki HoritaTakeshi Kaneko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.