The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy

Anesthesia and Analgesia
Chin-Chen ChuJhi-Joung Wang

Abstract

Haloperidol, a major tranquilizer, has been found to have a potent antiemetic effect on postoperative nausea and vomiting (PONV), but the prophylactic effect of haloperidol plus dexamethasone on PONV has not been evaluated. We evaluated the prophylactic effect of haloperidol plus dexamethasone to either given alone, placebo or droperidol on PONV in patients undergoing a laparoscopic-assisted vaginal hysterectomy. Four hundred adult women (n = 80 in each of five groups) scheduled for a laparoscopic-assisted vaginal hysterectomy were enrolled in a randomized, double-blind, placebo, and positive-control study. Fifteen minutes after the induction of anesthesia, patients received an i.v. injection of either saline (group S), droperidol 1.25 mg (group D), haloperidol 2 mg (group H), dexamethasone 5 mg (group Dx), or haloperidol 2 mg plus dexamethasone 5 mg (group H + Dx) to prevent PONV. The occurrence of PONV and medication-related side effects were recorded. The incidences of PONV (0-24 h) in the D (36%), H (37%), Dx (38%), and H + Dx (19%) groups were significantly lower than in the S group (65%; P < 0.05 for each comparison). The H + Dx group had the lowest incidence of PONV (19%; P < 0.05 for each comparison) of the five study g...Continue Reading

References

May 1, 1997·Anaesthesia·M KoivurantaS Alahuhta
Aug 16, 2001·Journal of Pain and Symptom Management·P CritchleyA R Jadad
Jan 4, 2003·European Journal of Anaesthesiology·N A Wisely, E A Shipton
Jun 17, 2004·Palliative Medicine·Jane Vella-Brincat, A D Macleod
Aug 31, 2004·Anesthesia and Analgesia·Chiu-Ming HoChok-Yung Chai
May 24, 2006·Anesthesia and Analgesia·Tong J Gan

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Citations

Aug 22, 2015·Expert Opinion on Drug Metabolism & Toxicology·Gina HendrenAnthony Kovac
Oct 11, 2011·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Chiu-Ming HoJhi-Joung Wang
Mar 26, 2009·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Ping-Hsun FengChin-Chen Chu
May 1, 2013·Journal of Pain & Palliative Care Pharmacotherapy·Samantha L McLeanMichael I Bennett
Nov 23, 2013·Revista brasileira de anestesiologia·Márcio Luiz BenevidesJosé Eduardo Aguilar-Nascimento
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Apr 19, 2008·Anesthesia and Analgesia·Ashraf S Habib, Tong J Gan
Apr 19, 2008·Anesthesia and Analgesia·Danielle B Ludwin, Steven L Shafer
Nov 15, 2008·Current Opinion in Anaesthesiology·Janet D Pavlin, Christopher D Kent
Jan 23, 2009·Anaesthesia and Intensive Care·H Gray
Dec 12, 2012·Anesthesia and Analgesia·Gildasio S De OliveiraRobert J McCarthy
Feb 1, 2013·Anesthesiology·Jeffrey L ApfelbaumUNKNOWN American Society of Anesthesiologists Task Force on Postanesthetic Care
May 30, 2020·Anesthesia and Analgesia·Tong J GanBeverly K Philip
Aug 18, 2018·Experimental and Therapeutic Medicine·Yurong XueYongquan Chen
Apr 30, 2017·Journal of Anesthesia·Xuezhao CaoHong Ma
Aug 16, 2017·Drugs & Aging·Xuezhao CaoHong Ma
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Apr 5, 2021·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Rachel C Wolfe, Jessica Bequette
Jun 20, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Matthew W VannemanAdam A Dalia

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