The prophylactic effects of platelet-leucocyte gel in osteomyelitis: an experimental study in a rabbit model

The Journal of Bone and Joint Surgery. British Volume
W-T JiaZ-S Ai

Abstract

Platelet-leucocyte gel (PLG), a new biotechnological blood product, has hitherto been used primarily to treat chronic ulcers and to promote soft-tissue and bone regeneration in a wide range of medical fields. In this study, the antimicrobial efficacy of PLG against Staphylococcus aureus (ATCC 25923) was investigated in a rabbit model of osteomyelitis. Autologous PLG was injected into the tibial canal after inoculation with Staph. aureus. The prophylactic efficacy of PLG was evaluated by microbiological, radiological and histological examination. Animal groups included a treatment group that received systemic cefazolin and a control group that received no treatment. Treatment with PLG or cefazolin significantly reduced radiological and histological severity scores compared to the control group. This result was confirmed by a significant reduction in the infection rate and the number of viable bacteria. Although not comparable to cefazolin, PLG exhibited antimicrobial efficacy in vivo and therefore represents a novel strategy to prevent bone infection in humans.

References

Jul 1, 1992·The Journal of Infectious Diseases·M R YeamanA S Bayer
Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
Jul 15, 1988·Annals of Internal Medicine·R I LehrerJ T Curnutte
Jan 1, 1995·Advances in Microbial Physiology·R E HancockM Brown
Feb 8, 1997·Lancet·R E Hancock
Mar 1, 1997·Infection and Immunity·M R YeamanM E Selsted
May 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M S SmeltzerR P Evans
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R Yeaman
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C von EiffG Peters
Oct 18, 2000·Journal of Biomedical Materials Research·M W NijhofA J Verbout
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·H Yan, R E Hancock
Jan 25, 2002·Nature·Michael Zasloff
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthias H F Klinger, Wolfgang Jelkmann
Nov 20, 2002·Infection and Immunity·Yi-Quan TangMichael E Selsted
Jul 28, 2004·Lancet·Daniel P Lew, Francis A Waldvogel
Nov 24, 2004·Clinical Orthopaedics and Related Research·Carl L Nelson
Aug 9, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·B RaiK H Ho
Apr 29, 2006·Acta Anaesthesiologica Scandinavica·P A M EvertsA van Zundert
Jun 29, 2006·Current Opinion in Infectious Diseases·Andrej Trampuz, Andreas F Widmer
Mar 16, 2007·The Journal of Bone and Joint Surgery. British Volume·T M BieleckiT Wielkoszynski
Apr 3, 2007·Journal of Periodontology·Hesham El-SharkawyThomas E Van Dyke
Oct 26, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dirk Jan F MoojenWouter J A Dhert
Jan 16, 2008·Journal of Biomaterials Applications· Hee Soon ChoMyun-Whan Ahn
May 8, 2008·The Journal of the American Academy of Orthopaedic Surgeons·Laura Prokuski

❮ Previous
Next ❯

Citations

May 31, 2013·Journal of the Royal Army Medical Corps·William G P EardleyJ C Clasper
Jan 3, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Guang-Yi LiChang-Qing Zhang
Mar 10, 2011·Tissue Engineering. Part a·Rania El BacklyMaddalena Mastrogiacomo
Mar 16, 2019·Journal of Medical Microbiology·Marta BottagisioArianna B Lovati
May 19, 2017·Tissue Engineering and Regenerative Medicine·Tomasz SzponderAnna Smolira
Apr 18, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wen-Jing YinChang-Qing Zhang
Feb 5, 2019·Tissue Engineering. Part B, Reviews·Wenhai ZhangBin Duan
Dec 10, 2019·Korean Journal of Orthodontics·Theerasak NakornnoiBancha Samruajbenjakun
Jan 6, 2021·Platelets·Peter A EvertsRonald D Gardner

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.