The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers.

Cell Communication and Signaling : CCS
Juan WangYing Yuan

Abstract

The (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR pathways, that are involved in a wide range of physiological and pathological processes incorporating the tumorigenesis. However, our knowledge about (P) RR was mostly limited to its roles in cardiovascular and renal physiological functions and diseases. In the past 5 years, however, compelling evidence has revealed that (P) RR is aberrantly expressed in and contributes to the development of various cancers by different means. For instance, (P) RR was recently demonstrated to induce the oncogenesis of pancreatic, colorectal and brain cancers via the Wnt signaling, while promote the endometrial cancer and glioblastoma through the RAS. Combining with the deep analysis of big data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, this review updates and summarizes the recent studies about the newly recognized roles of (P) RR in the pathophysiological processes of cancer development and its detailed functions through related pathways, as well as the novel research progress of (P) RR in related fields including the development and applicat...Continue Reading

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Citations

Aug 25, 2020·American Journal of Physiology. Renal Physiology·Maki UrushiharaShoji Kagami
Sep 16, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B AfsarM Kanbay
Feb 14, 2021·Diagnostics·Jon Danel Solano-IturriGorka Larrinaga
Oct 31, 2020·Cancer Management and Research·Kankan ZhaoAiguo Wu
Aug 28, 2021·Cancers·Michael O'RaweAgadha C Wickremesekera

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Methods Mentioned

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ubiquitination
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