The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome

Kidney International
Nirupama Ramkumar, Donald E Kohan

Abstract

The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.

Citations

May 14, 2019·Hypertension·Yuan SunA H Jan Danser
Dec 17, 2019·American Journal of Physiology. Renal Physiology·Fei WangTianxin Yang
Mar 24, 2020·Hypertension·Yuan SunA H Jan Danser
Jun 21, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George O A Naik
Aug 25, 2020·American Journal of Physiology. Renal Physiology·Maki UrushiharaShoji Kagami
Apr 22, 2020·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Moe EndoKazuhiro Takahashi
Mar 17, 2020·Current Hypertension Reports·Yuan SunA H Jan Danser
Apr 3, 2020·Nature Reviews. Nephrology·Matias SimonsDominik N Müller
Sep 8, 2020·Current Hypertension Reports·Premjith Gathiram, Jagidesa Moodley
Aug 18, 2020·American Journal of Physiology. Renal Physiology·Fei WangTianxin Yang
Dec 17, 2020·American Journal of Physiology. Cell Physiology·Amity F EatonDennis Brown
Dec 19, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sven Kurbel
Apr 24, 2021·Circulation Research·Nirupama RamkumarDonald E Kohan
Jun 5, 2021·Cellular and Molecular Gastroenterology and Hepatology·Yun-Cheng HsiehHan-Chieh Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

Current Opinion in Pharmacology
Geneviève Nguyen, Aurélie Contrepas
Journal of the American Society of Nephrology : JASN
Geneviève Nguyen, Dominik N Müller
Journal of the American Society of Hypertension : JASH
Geneviève Nguyen
Pflügers Archiv : European journal of physiology
Jörg Peters
© 2022 Meta ULC. All rights reserved