Aug 1, 1989

The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome

The EMBO Journal
C HaassP M Kloetzel

Abstract

The proteasome is a multicatalytic proteinase complex composed of nonidentical protein subunits. We have isolated a cDNA clone encoding the 35 kd proteasome subunit of Drosophila melanogaster and propose the designation PROS-35 for the corresponding gene. The deduced amino acid sequence reveals a region of striking homology to a tyrosine phosphorylation site of viral and cellular proteins suggesting a potential regulatory function for the 35 kd subunit within the proteinase complex. Immunocytochemical experiments reveal a tissue-dependent differential distribution of the proteasome between the nucleus and cytoplasm. In addition developmental analysis shows that the proteasome is highly expressed in the CNS of stage-16 embryos and in cardia, ventriculus and ovaries of adult flies. These data suggest a tissue- and development-dependent distribution of the proteasome in D. melanogaster.

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Mentioned in this Paper

Embryo
Proteasome Pathway
Gizzard
Adenine Polynucleotides
Both Ovaries
Ovary
Prosalpha6
Immunocytochemistry
Endopeptidases
Tyrosine Phosphorylation Site

About this Paper

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