The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD

The American Journal of Psychiatry
Christopher D SchneckGary S Sachs

Abstract

In a naturalistic follow-up of adult bipolar patients, the authors examined the contributions of demographic, phenomenological, and clinical variables, including antidepressant use, to prospectively observed mood episode frequency. For 1,742 bipolar I and II patients in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), episodes of mood disorders were evaluated for up to 1 year of treatment. At entry, 32% of the patients met the DSM-IV criteria for rapid cycling in the prestudy year. Of the 1,742 patients, 551 (32%) did not complete 1 year of treatment. Among the 1,191 patients remaining, those with prior rapid cycling (N=356) were more likely to have further recurrences, although not necessarily more than four episodes per year. At the end of 12 months, only 5% (N=58) of the patients could be classified as rapid cyclers; 34% (N=409) had no further mood episodes, 34% (N=402) experienced one episode, and 27% (N=322) had two or three episodes. Patients who entered the study with earlier illness onset and greater severity were more likely to have one or more episodes in the prospective study year. Antidepressant use during follow-up was associated with more frequent mood episodes. While DSM-IV rapid cycli...Continue Reading

Citations

May 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Konstantinos N FountoulakisEduard Vieta
Mar 4, 2010·Archives of Women's Mental Health·Cheryl Ann Chessick, Sona Dimidjian
Jun 30, 2009·Advances in Therapy·David E KempRoger S McIntyre
Nov 11, 2009·Current Opinion in Psychiatry·Konstantinos N Fountoulakis
Dec 3, 2009·Current Opinion in Psychiatry·Johannes Hebebrand
Jun 21, 2013·Neuropsychiatric Disease and Treatment·Calvert G Warren, Steven L Dubovsky
Oct 7, 2011·The Primary Care Companion to CNS Disorders·Roger Sparhawk, S Nassir Ghaemi
Mar 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Sing LeeMaria Petukhova
Oct 27, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Jay D AmsterdamJustine Shults
Nov 5, 2010·International Review of Psychiatry·Arianna Diflorio, Ian Jones
Jul 1, 2009·Expert Review of Clinical Pharmacology·Vivek Datta, Anthony J Cleare
Jan 9, 2013·Expert Opinion on Drug Metabolism & Toxicology·Steven L Dubovsky
Jan 25, 2016·Acta Psychiatrica Scandinavica·L Lorenzo-LuacesR J DeRubeis
Mar 14, 2012·Journal of Affective Disorders·Eunsoo MoonKyooseob Ha
Jul 2, 2011·Journal of Affective Disorders·Martin Bürgy
Nov 26, 2010·Journal of Affective Disorders·Judith ProudfootGordon Parker
Nov 13, 2015·Psychiatry Research·Filiz OzdemirogluFatih Vahapoglu
Feb 27, 2013·Bipolar Disorders·Konstantinos N FountoulakisLakshmi N Yatham
Apr 25, 2012·Bipolar Disorders·Gin S MalhiMichael Gitlin
Nov 20, 2009·Bipolar Disorders·Cheryl A ChessickUNKNOWN STED-BD Family Experience Collaborative Study Group
Jul 27, 2015·Journal of Affective Disorders·Jan ScottNicol Ferrier
Dec 23, 2014·Journal of Affective Disorders·Alina KarantiMikael Landén
Jul 6, 2015·Journal of Affective Disorders·Rif S El-MallakhS Nassir Ghaemi
Apr 30, 2015·Asian Journal of Psychiatry·Serap OflazEsat Timucin Oral
May 24, 2015·Journal of Affective Disorders·Emmanuelle C S BostockBruce V M Taylor
Jul 31, 2012·Journal of Affective Disorders·Gregory G HomishKenneth Leonard
Jan 21, 2014·Journal of Affective Disorders·Niki Antypa, Alessandro Serretti
Dec 22, 2014·Journal of Affective Disorders·Andrée DaigneaultSerge Beaulieu
Aug 4, 2012·Journal of Affective Disorders·Jeffrey J Rakofsky, Boadie W Dunlop
Apr 17, 2014·Experimental Neurobiology·Chansoo JunIn Kyoon Lyoo
Oct 12, 2016·Translational Psychiatry·A L CochranD B Forger
Oct 25, 2016·Journal of Affective Disorders·Ling ZhangYu-Tao Xiang

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

MINI Plus
STEP
BD

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.