The Prostate Cancer Intervention Versus Observation Trial: a randomized trial comparing radical prostatectomy versus expectant management for the treatment of clinically localized prostate cancer

The Journal of Urology
Timothy J Wilt, Michael K Brawer

Abstract

The Prostate Cancer Intervention Versus Observation Trial (PIVOT) is a randomized controlled trial sponsored by the Department of Veterans Affairs and the National Cancer Institute. PIVOT will enroll 2,000 participants from at least 80 Veterans Administration and National Cancer Institute medical centers. The purpose of PIVOT is to determine which of 2 strategies is superior for managing clinically localized prostate cancer (stage T1/T2NXM0) of all histological grades. Patients less than 75 years old will be randomized to either radical prostatectomy with early intervention for disease persistence/recurrence or expectant management with palliative therapy reserved for symptomatic or metastatic disease progression. Participants will be excluded if they have received prior therapy for prostate cancer (except transurethral resection of the prostate) or are judged not to be candidates for radical prostectomy. All patients with newly diagnosed prostate cancer will be recorded on the PIVOT screening log. Registry information will include patient age, race, prostate specific antigen level, clinical stage, histological tumor grade, initial therapy, and vital status. Patients meeting eligibility criteria will watch an information and ra...Continue Reading

References

Nov 1, 1989·American Journal of Public Health·J W Horm, E J Sondik
Mar 22, 1984·The New England Journal of Medicine·UNKNOWN CASS Principal Investigators and Their Associates
May 27, 1982·The New England Journal of Medicine·B J McNeilA Tversky
Nov 1, 1993·Annals of Internal Medicine·B S KramerJ K Gohagan
Jan 27, 1994·The New England Journal of Medicine·G W ChodakJ Warner
Jul 1, 1993·Journal of General Internal Medicine·D J Mazur, D H Hickman

❮ Previous
Next ❯

Citations

Jul 9, 1999·Journal of Epidemiology and Community Health·D L Weed
Jun 3, 1999·Evaluation & the Health Professions·J N Lewis, W Rising
May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
May 1, 1995·Cancer Causes & Control : CCC·J W Waterbor, A J Bueschen
Mar 6, 1998·Journal of the Royal Society of Medicine·M R Feneley, C Busch
May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
Mar 5, 2003·BJU International·R S Kirby, J M Fitzpatrick
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shabbir M H AlibhaiMurray D Krahn
Nov 29, 2005·British Journal of Hospital Medicine·J L DonovanF C Hamdy
Dec 28, 2007·The New England Journal of Medicine·Patrick C WalshMario A Eisenberger
Jun 11, 2010·Japanese Journal of Clinical Oncology·Mikio SugimotoYoshiyuki Kakehi
Dec 25, 2015·Journal of the American Society of Nephrology : JASN·Gerardo A VitielloNicole Turgeon
Jan 24, 2018·The Journal of Urology·Samir S Taneja
Aug 12, 1998·British Journal of Urology·P FitzpatrickJ M Fitzpatrick
Nov 5, 1997·Cancer·F Abbas, P T Scardino
Jul 27, 1999·The Prostate·N J HegartyD S Coffey
Oct 14, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiko HachiyaYukie Takimoto
Jan 13, 2006·Prostate Cancer and Prostatic Diseases·V BhatnagarR M Kaplan
Aug 13, 2008·Journal of the National Cancer Institute·Anna Bill-AxelsonUNKNOWN Scandinavian Prostate Cancer Group Study Number 4
Jun 15, 2017·Revista da Associação Médica Brasileira·Samir Abdallah HannaUNKNOWN Brazilian Society of Radiotherapy (SBR)
Apr 1, 1997·British Journal of Urology·C C Schulman
Apr 16, 1998·Journal of the Royal Society of Medicine·F Chinegwundoh
Apr 28, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M MoinpourC A Coltman
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Josephine HegartyMeredith Wallace Kazer
Jun 5, 2020·The Cochrane Database of Systematic Reviews·Robin Wm VernooijKatja Kh Aben
Aug 14, 1998·Japanese Journal of Cancer Research : Gann·N YoshimuraO Yoshida
Jan 5, 2000·Seminars in Surgical Oncology·M K Brawer
Feb 7, 2009·The Cancer Journal·John Concato
Oct 31, 2019·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·Xiaojin LuoWeihua Yin
Sep 1, 2005·Prostate Cancer and Prostatic Diseases·M A Khan, A W Partin
Feb 6, 1998·The Medical Journal of Australia·C S Hamilton
Mar 4, 2021·World Journal of Urology·Colton H WalkerTodd M Morgan
Oct 5, 2001·Disease-a-month : DM·J A Eastham, P T Scardino
Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G BorghedeC Mercke

❮ Previous
Next ❯

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